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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Safety of artemisinins during early pregnancy, assessed in 62 Sudanese women
Annals of Tropical Medicine and Parasitology, Volume 103, No. 3, Year 2009
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Description
Between June 2006 and October 2008, the safety of artemisinins during early human pregnancy was assessed in central-eastern Sudan. Pregnant women in the first or second trimester who were attending antenatal-care clinics at the Wad Medani, Gadarif and New Halfa hospitals were interviewed. Each was asked if they had had malaria in the first trimester of the index pregnancy and, if so, what treatment they had received. The women who had received artemisinins were then followed-up until delivery and their babies were followed-up until they were 1-yearolds. Overall, 62 of the pregnant women reported receiving artemisinins - artemether injections (48), artesunate plus sulfadoxine-pyrimethamine (11) or artemether plus lumefantrine (three) - during the first trimester. Medical records were available for 51 (82%) of these 62 women, and, in each case, these records showed the reported treatment and that malaria had been confirmed. Only nine (15%) of the 62 women given artemisinins had not known that they were pregnant when treated. Two of the treated women (both given artemether injections in the first trimester) had miscarriages, one at 20 weeks of gestation and the other at 22 weeks, each while receiving quinine infusions for a second attack of malaria. The other 60 women who had received artemisinins delivered apparently healthy babies at full term. No congenital malformations were detected, there was no preterm labour, no maternal deaths were recorded during the follow-up, and none of the babies died during their first year of life. It therefore appears that artemisinins may be safe to use during early pregnancy, although further study is clearly needed. © The Liverpool School of Tropical Medicine 2009.
Authors & Co-Authors
Adam, Ishag I.
Sudan, Khartoum
University of Khartoum Faculty of Medicine
Elhassan, M. Elhassan
Sudan, Wad Medani
University of Gezira
Omer, Elsir Sir M.
Sudan
New Halfa Teaching Hospital
Abdulla, Mohamed A.
Sudan, El-gadarif
University of Gadarif
Mahgoub, Hyder M.
Sudan
New Halfa Teaching Hospital
Adam, Gamal K.
Sudan, El-gadarif
University of Gadarif
Statistics
Citations: 47
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1179/136485909X398285
ISSN:
00034983
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Sudan
Participants Gender
Female