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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Initial B-cell responses to transmitted human immunodeficiency virus type 1: Virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia
Journal of Virology, Volume 82, No. 24, Year 2008
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Description
A window of opportunity for immune responses to extinguish human immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through establishment of the latent pool of HIV-1-infected cells. A critical time to study the initial immune responses to the transmitted/founder virus is the eclipse phase of HIV-1 infection (time from transmission to the first appearance of plasma virus), but, to date, this period has been logistically difficult to analyze. To probe B-cell responses immediately following HIV-1 transmission, we have determined envelope-specific antibody responses to autologous and consensus Envs in plasma donors from the United States for whom frequent plasma samples were available at time points immediately before, during, and after HIV-1 plasma viral load (VL) ramp-up in acute infection, and we have modeled the antibody effect on the kinetics of plasma viremia. The first detectable B-cell response was in the form of immune complexes 8 days after plasma virus detection, whereas the first free plasma anti-HIV-1 antibody was to gp41 and appeared 13 days after the appearance of plasma virus. In contrast, envelope gp120-specific antibodies were delayed an additional 14 days. Mathematical modeling of the earliest viral dynamics was performed to determine the impact of antibody on HIV replication in vivo as assessed by plasma VL. Including the initial anti-gp41 immunoglobulin G (IgG), IgM, or both responses in the model did not significantly impact the early dynamics of plasma VL. These results demonstrate that the first IgM and IgG antibodies induced by transmitted HIV-1 are capable of binding virions but have little impact on acute-phase viremia at the timing and magnitude that they occur in natural infection. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2593361/bin/supp_82_24_12449__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2593361/bin/supp_82_24_12449__JVI01708_08_Supporting_Online_Materials_.zip
Authors & Co-Authors
Tomaras, Georgia D.
United States, Durham
Duke University School of Medicine
United States, Durham
Duke University Medical Center
Yates, Nicole L.
United States, Durham
Duke University School of Medicine
Liu, Pinghuang
United States, Durham
Duke University School of Medicine
Qin, Li
United States, Seattle
Fred Hutchinson Cancer Research Center
Fouda, Genevieve G.A.
United States, Durham
Duke University School of Medicine
Chavez, Leslie L.
United States, Los Alamos
Los Alamos National Laboratory
DeCamp, Allan C.
United States, Seattle
Fred Hutchinson Cancer Research Center
Parks, Robert J.
United States, Durham
Duke University School of Medicine
Ashley, Vicki
United States, Durham
Duke University School of Medicine
Lucas, Judith T.
United States, Durham
Duke University School of Medicine
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Eron, Joseph J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hicks, Charles B.
United States, Durham
Duke University School of Medicine
Liao, Huaxin
United States, Durham
Duke University School of Medicine
Self, Steven G.
United States, Seattle
Fred Hutchinson Cancer Research Center
Landucci, Gary R.
United States, Irvine
University of California, Irvine
Forthal, Donald N.
United States, Irvine
University of California, Irvine
Weinhold, Kent J.
United States, Durham
Duke University School of Medicine
Keele, Brandon F.
United States, Birmingham
The University of Alabama at Birmingham
Hahn, Beatrice H.
United States, Birmingham
The University of Alabama at Birmingham
Greenberg, Michael L.
United States, Durham
Duke University School of Medicine
United States, Research Triangle Park
B3 Bio., Inc.
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Blattner, William A.
United States, Baltimore
University of Maryland, Baltimore Umb
Montefiori, David Charles
United States, Durham
Duke University School of Medicine
Shaw, George M.
United States, Birmingham
The University of Alabama at Birmingham
Perelson, Alan S.
United States, Los Alamos
Los Alamos National Laboratory
Haynes, Barton F.
United States, Durham
Duke University School of Medicine
Statistics
Citations: 614
Authors: 28
Affiliations: 11
Identifiers
Doi:
10.1128/JVI.01708-08
ISSN:
0022538X
Research Areas
Infectious Diseases