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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Rate of decline of absolute number and percentage of CD4 T lymphocytes among HIV-1-infected adults in Dar es Salaam, Tanzania
AIDS, Volume 18, No. 3, Year 2004
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Description
Objective: To determine the rate of decline of CD4 T lymphocytes among HIV-1-infected individuals. Design and setting: A prospective open cohort study of workers in three hotels in Dar es Salaam. Methods: The workers were seen yearly during the study. CD4 T lymphocyte counts were determined using flow cytometry. The CD4 T-lymphocyte slopes were determined using a linear regression model. Results: During the 9-year study period 682 subjects were selected for lymphocyte subset determinations. Of these, 94 HIV-1-seroprevalent (72%), 77 HIV-1-seroincident (67%) and 325 seronegative (75%) individuals had three or more CD4 T-cell determinations, and were used for calculations of CD4 cell slopes with a mean follow-up period of 71.4, 52.9 and 86.0 months, respectively. The median yearly decline of the CD4 T-lymphocyte counts and percentages among seroprevalent individuals was -21.5 cells/μl and -1.3%; among the seroincident individuals the median decline was -22.0 cells/μl and -1.5%. In seroincident individuals the mean duration to a CD4 T-lymphocyte level corresponding to a definition of AIDS was 13.3 years or 11.8 years for CD4 cell counts or percentages, respectively. HIV-1-seropositive subjects who died had significantly steeper CD4 cell slopes than those who survived. Conclusion: The rates of CD4 T-lymphocyte decline in HIV-1-infected individuals in our population are similar to those reported in Europe and north America. © 2004 Lippincott Williams & Wilkins.
Authors & Co-Authors
Urassa, Willy K.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Bakari, Muhammad
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Sandström, Eric G.
Sweden, Stockholm
Södersjukhuset
Swai, Andrew Babu M.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Pallangyo, Kisali J.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Mbena, Ephraim C.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Mhalu, Frederick S.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Biberfeld, Gunnel
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 53
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1097/00002030-200402200-00009
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Tanzania