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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Geographic diversity of human immunodeficiency virus type 1: Serologic reactivity to env epitopes and relationship to neutralization
Journal of Infectious Diseases, Volume 165, No. 2, Year 1992
Notification
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Description
The antibody recognition of the major neutralization epitopes of human immunodeficiency virus type 1 (HIV-1) in 829 HIV-1-seropositive subjects from North America (106), Europe (241), Africa (342), and Asia (100) was investigated. Peptides derived from diverse published V3 loop sequences were used as antigen, and serum reactivity was detected by sensitive ELISAs. Antibody binding to peptides derived from the V3 loop sequence of HIV-1 isolates varies considerably depending on the geographic origin of the antibody and is associated with neutralization titer against homologous isolates. Serotype reactivity to peptides may be a simple and rapid approach to investigation of HIV-1 env diversity worldwide and may assist the choice of immunogen for development of future AIDS vaccines. © 1992 Oxford University Press.
Authors & Co-Authors
Cheingsong-Popov, Rachanee
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Callow, David
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Beddows, Simon A.
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Shaunak, Sunil
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Wasi, Chantapong
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Kaleebu, Pontiano P.
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Gilks, Charles F.
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Petrascu, Ionel V.
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Garaev, Mansur M.
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Watts, Douglas M.
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Constantine, Niel T.
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Weber, Jonathan N.
United Kingdom, London
Imperial College London
Thailand, Bangkok
Who Collaborating Center for Research on Rabies Pathogenesis and Prevention
Uganda, Entebbe
Uganda Virus Research Institute
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Romania, Bucharest
Romanian Water Association
Russian Federation, Moscow
D.i. Ivanovsky Institute of Virology
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 49
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1093/infdis/165.2.256
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Infectious Diseases