Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Pharmacokinetics and bioavailability of ranitidine in humans
Journal of Pharmaceutical Sciences, Volume 73, No. 10, Year 1984
Notification
URL copied to clipboard!
Description
Ranitidine produces a blood concentration curve with a pronounced secondary peak when administered orally and parenterally. A pharmacokinetic model is proposed to describe this reabsorption phenomenon. The choice of a discontinuous cyclic transfer was justified on the basis of physiological considerations and the good agreement with data from oral and intravenous administration. It is proposed that ranitidine accumulates mainly from the systemic circulation into a depot from which drug and bioreversible drug are spontaneously released in response to food intake. The evaluation of the extent of the first‐pass effect and the evaluation of bioequivalency are complicated by the model‐independent AUC approach because the area under the concentration versus time curve (AUC) is dependent on the extent of recycling and thus does not properly reflect the extent of primary absorption. By using intravenous administration as a reference dosage form and the integrated form of the regression equations to calculate the AUC values, the bioavailability of the oral dose was found to be 0.56, which corresponds well with the value of 0.58 obtained by linear‐log‐linear integration. The least‐squares parameter estimate of the primary absorption is 0.43. Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Miller, Raymond
South Africa, Potchefstroom
North-west University
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 84
Authors: 1
Affiliations: 2
Identifiers
Doi:
10.1002/jps.2600731013
ISSN:
00223549
e-ISSN:
15206017
Research Areas
Food Security
Health System And Policy