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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Glutathione S‐Transferase in Human Hepatocellular Carcinoma
Hepatology, Volume 3, No. 2, Year 1983
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Description
Qualitative and quantitative changes in glutathione S‐transferase (GSH‐T) were studied in human hepatocellular carcinoma. GSH‐T specific activity (/imoles per min per mg protein) was variably reduced in hepatocellular carcinoma. Similar changes were seen in “cationic” GSH‐T (ligandin) concentration determined by radioimmunoassay. Immunohistochemical studies with antihuman liver ligandin suggest that positive staining was more frequently found in well‐differentiated tumors. The relative activities of “cationic,” “neutral,” and “anionic” transferases were estimated after separation by isoelectric focusing. Tumor “cationic” transferase (pI ± 7.5) activity ranged from virtually absent to near normal values. “Neutral” (pI 6 to 6.5) and “anionic” (pI < 5.4) species were present more often in tumors than in normal liver. In two cases, normal liver tissue and tumor were obtained from the same patient. In one, only quantitative differences were present, while in the other “cationic” and “neutral” GSH‐Ts were present in the normal liver tissue while both “cationic” and “anionic” species were found in the tumor. Our studies indicate that qualitative as well as quantitative changes of GSH‐T occur in human hepatocellular carcinoma. Copyright © 1983 American Association for the Study of Liver Diseases
Authors & Co-Authors
Sherman, M.
South Africa, Cape Town
University of Cape Town
Campbell, John A.H.
South Africa, Cape Town
University of Cape Town
Titmuss, Sally A.
South Africa, Cape Town
University of Cape Town
Kew, Michael Charles
South Africa, Cape Town
University of Cape Town
Kirsch, Ralph Emmanuel
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 32
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1002/hep.1840030206
ISSN:
02709139
Research Areas
Cancer
Health System And Policy
Study Approach
Qualitative
Quantitative