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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group
Biological Psychiatry, Volume 91, No. 6, Year 2022
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Description
Background: Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whether such alterations progressively change over time, and how this is related to the number of mood episodes. To address this question, we analyzed a large and diverse international sample with longitudinal magnetic resonance imaging (MRI) and clinical data to examine structural brain changes over time in BD. Methods: Longitudinal structural MRI and clinical data from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307 patients with BD and 925 healthy control subjects, were collected from 14 sites worldwide. Male and female participants, aged 40 ± 17 years, underwent MRI at 2 time points. Cortical thickness, surface area, and subcortical volumes were estimated using FreeSurfer. Annualized change rates for each imaging phenotype were compared between patients with BD and healthy control subjects. Within patients, we related brain change rates to the number of mood episodes between time points and tested for effects of demographic and clinical variables. Results: Compared with healthy control subjects, patients with BD showed faster enlargement of ventricular volumes and slower thinning of the fusiform and parahippocampal cortex (0.18 < d < 0.22). More (hypo)manic episodes were associated with faster cortical thinning, primarily in the prefrontal cortex. Conclusions: In the hitherto largest longitudinal MRI study on BD, we did not detect accelerated cortical thinning but noted faster ventricular enlargements in BD. However, abnormal frontocortical thinning was observed in association with frequent manic episodes. Our study yields insights into disease progression in BD and highlights the importance of mania prevention in BD treatment. © 2021 Society of Biological Psychiatry
Authors & Co-Authors
Abé, Christoph
Sweden, Stockholm
Karolinska Institutet
Ching, Christopher R.K.
United States, Los Angeles
University of Southern California
Liberg, Benny
Sweden, Stockholm
Karolinska Institutet
Agartz, Ingrid A.
Sweden, Stockholm
Karolinska Institutet
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Akudjedu, Theophilus N.
United Kingdom, Bournemouth
Bournemouth University
Ireland, Galway
University of Galway
Alda, Martin
Canada, Halifax
Dalhousie University
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Alnæs, Dag
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Bjorknes University College
Alonso-Lana, Silvia
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Benedetti, Francesco
Italy, Milan
Irccs Ospedale San Raffaele
Italy, Milan
Università Vita-salute San Raffaele
Germany, Munster
University of Münster
Berk, Michael
Australia, Melbourne
Orygen Youth Health
Australia, Clayton
Monash University
Australia, Geelong
Barwon Health
Bøen, Erlend
Norway, Oslo
Oslo Universitetssykehus
Bonnín, Caterina Del Mar
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Spain, Barcelona
Hospital Clinic Barcelona
Spain, Barcelona
Universitat de Barcelona
Brosch, Katharina
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Brouwer, Rachel M.
Netherlands, Utrecht
Universiteit Utrecht
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Canales-Rodríguez, Erick Jorge
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Switzerland, Lausanne
École Polytechnique Fédérale de Lausanne
Cannon, Dara M.
Ireland, Galway
University of Galway
Chye, Yann
Australia, Clayton
Monash University
Dahl, Andreas
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Dandash, Orwa
Australia, Melbourne
University of Melbourne
Dannlowski, Udo
Germany, Munster
University of Münster
Dohm, Katharina
Germany, Munster
University of Münster
Elvsåshagen, Torbjorn
Norway, Oslo
Oslo Universitetssykehus
Fullerton, Janice M.
Australia, Sydney
Unsw Sydney
Australia, Sydney
Neuroscience Research Australia
Goikolea, José M.
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Spain, Barcelona
Hospital Clinic Barcelona
Spain, Barcelona
Universitat de Barcelona
Grotegerd, Dominik
Germany, Munster
University of Münster
Haatveit, Beathe C.
Norway, Oslo
Oslo Universitetssykehus
Hahn, Tim
Canada, Halifax
Dalhousie University
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Germany, Munster
University of Münster
Haj́ek, Tomaś
Canada, Halifax
Dalhousie University
Czech Republic, Klecany
Národní Ústav Duševního Zdraví, Klecany
Germany, Munster
University of Münster
Heindel, Walter Leonhard
Germany, Munster
University of Münster
Ingvar, Martin C.
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sim, Kang
Singapore, Singapore City
Lee Kong Chian School of Medicine
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Singapore Institute of Mental Health
Germany, Munster
University of Münster
Kircher, Tilo T.J.
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Lenroot, Rhoshel K.
United States, Albuquerque
The University of new Mexico
Malt, Ulrik Fredrik
Norway, Oslo
Oslo Universitetssykehus
McDonald, Colm D.
Ireland, Galway
University of Galway
McWhinney, Sean R.
Canada, Halifax
Dalhousie University
Melle, Ingrid S.
Norway, Oslo
Oslo Universitetssykehus
Meller, Tina
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Melloni, Elisa Maria Teresa
Italy, Milan
Irccs Ospedale San Raffaele
Italy, Milan
Università Vita-salute San Raffaele
Mitchell, Philip B.
Australia, Sydney
Unsw Sydney
Nabulsi, Leila
United States, Los Angeles
University of Southern California
Ireland, Galway
University of Galway
Nenadić, Igor
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Opel, Nils
Germany, Munster
University of Münster
Overs, Bronwyn J.
Australia, Sydney
Neuroscience Research Australia
Pfarr, Julia Katharina
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Poletti, Sara
Italy, Milan
Irccs Ospedale San Raffaele
Pomarol-Clotet, Edith
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Radua, Joaquim
Sweden, Stockholm
Karolinska Institutet
United Kingdom, London
King's College London
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Germany, Munster
University of Münster
Repple, Jonathan
Sweden, Stockholm
Karolinska Institutet
United Kingdom, London
King's College London
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Germany, Munster
University of Münster
Ringwald, Kai Gustav
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Roberts, Gloria M.P.
Australia, Sydney
Unsw Sydney
Rodríguez-Cano, Elena
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Sant Boi de Llobregat
Hospital Benito Menni
Salvador, Raymond
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Sarró, Salvador
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Schmitt, Simon
Spain, Barcelona
Fidmag Germanes Hospitalàries Research Foundation
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Germany, Hannover
Hannover Medical School
Stein, Frederike
Germany, Marburg
Philipps-universität Marburg
Germany, Giessen
Justus-liebig-universität Gießen
Thomopoulos, Sophia I.
United States, Los Angeles
University of Southern California
Vieta, Eduard
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Spain, Barcelona
Hospital Clinic Barcelona
Spain, Barcelona
Universitat de Barcelona
Westlye, Lars T.
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Yatham, Lakshmi N.
Canada, Vancouver
The University of British Columbia
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Andreassen, Ole Andreas
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Landén, Mikaél
Sweden, Stockholm
Karolinska Institutet
Sweden, Gothenburg
Göteborgs Universitet
Statistics
Citations: 25
Authors: 63
Affiliations: 41
Identifiers
Doi:
10.1016/j.biopsych.2021.09.008
ISSN:
00063223
Research Areas
Genetics And Genomics
Mental Health
Study Design
Cohort Study
Participants Gender
Male
Female