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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Changes in maternal blood concentrations of selected essential and toxic elements during and after pregnancy
Journal of Environmental Monitoring, Volume 13, No. 8, Year 2011
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Description
The objective of this study was to investigate changes in the levels of toxic and essential elements in maternal blood during pregnancy and subsequently. A subset of 211 pregnant women from the North Norwegian Mother-and-Child Study was included. Blood samples were collected during the 2 nd trimester (P1) and postpartum (day 3, P2; and 6 weeks, P3) in different regions of northern Norway, and were analyzed for a suite of 10 selected elements. The latter feature three general but distinct concentration patterns across the three collection periods, namely: progressive increase [Group 1: As, Cd (non-smokers only), Mn, Pb and Zn]; V-shaped, with a minimum at P2 [Group 2: Cd (smokers), Hg, Mo and Se]; and downward V, with a maximum at P2 [Group 3: Co and Cu]. These trends are interpreted in the context of underlying metabolic, hematological and physiological changes that occur in mothers, as well the biochemistry and accumulation preferences of these elements within the whole blood compartment and breast milk. Implications for biomonitoring strategies are discussed. In a multivariable analysis of the P1 data, fish consumption was a robust positive predictor for Hg (p < 0.02), As (p < 0.01) and Se (p ≤ 0.001) blood concentrations, multivitamin intake for Se (p < 0.001), and parity for Co (p < 0.002); age reached significance only for Hg (p < 0.001). An inverse association was observed between parity and Hg (p < 0.05). For the other elements, predictor patterns were not evident. © 2011 The Royal Society of Chemistry.
Authors & Co-Authors
Hansen, Solrunn
Norway, Tromso
Uit Norges Arktiske Universitet
Nieboer, Evert
Norway, Tromso
Uit Norges Arktiske Universitet
Canada, Hamilton
Mcmaster University
Sandanger, Torkjel Manning
Norway, Tromso
Uit Norges Arktiske Universitet
Norway, Skedsmokorset
Norsk Institutt for Luftforskning
Wilsgaard, Tom
Norway, Tromso
Uit Norges Arktiske Universitet
Thomassen, Yngvar
Norway, Oslo
Statens Arbeidsmiljøinstitutt
Veyhe, Anna Sofía
Norway, Tromso
Uit Norges Arktiske Universitet
Odland, Jon Øyvind
Norway, Tromso
Uit Norges Arktiske Universitet
Statistics
Citations: 62
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1039/c1em10051c
ISSN:
14640333
Research Areas
Environmental
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Participants Gender
Female