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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Highly hydrophilic surfaces from polyglycidol grafts with dual antifouling and specific protein recognition properties
Langmuir, Volume 27, No. 15, Year 2011
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Description
Homopolymer grafts from α-tert-butoxy-ω-vinylbenzyl- polyglycidol (PGL) were prepared on gold and stainless steel (SS) substrates modified by 4-benzoyl-phenyl (BP) moieties derived from the electroreduction of the parent salt 4-benzoyl benzene diazonium tetrafluoroborate. The grafted BP aryl groups efficiently served to surface-initiate photopolymerization (SIPP) of PGL. In similar conditions, SIPP of hydroxyethyl methacrylate (HEMA) permitted the production of PHEMA grafts as model surfaces. Water contact angles were found to be 66°, 15°, and 0° for SS-BP, SS-PHEMA, and SS-PPGL, respectively. The spontaneous spreading of water drops on SS-PPGL was invariably observed with 1.5 μL water drops. PPGL thus appears as a superhydrophilic polymer. Resistance to nonspecific adsorption of proteins of PPGL and PHEMA grafts on gold was evaluated by surface plasmon resonance (SPR) using antibovine serum albumin (anti-BSA). The results conclusively show that PPGL-grafts exhibit enhanced resistance to anti-BSA adsorption compared to the well-known hydrophilic PHEMA. PPGL grafts were further modified with BSA through the carbonyldiimidazole activation of the OH groups providing immunosensing surfaces. The so-prepared PPGL-grafted BSA hybrids specifically interacted with anti-BSA in PBS as compared to antimyoglobin. It is clear that the superhydrophilic character of PPGL grafts opens new avenues for biomedical applications where surfaces with dual functionality, namely, specific protein grafting together with resistance to biofouling, are required. © 2011 American Chemical Society.
Authors & Co-Authors
Gam-Derouich, Sarra
France, Paris
Interfaces Traitements Organisation et Dynamique Des Systèmes – Itodys
Gosecka, Monika
Poland, Lodz
Institute - Center for Molecular and Macromolecular Studies of the Polish Academy of Sciences
Lépinay, Sandrine
France, Thiais
Institut de Chimie et Des Matériaux de Paris Est Icmpe - Umr7182
Turmine, Mireille
France, Paris
Sorbonne Université
Carbonnier, Benjamin
France, Thiais
Institut de Chimie et Des Matériaux de Paris Est Icmpe - Umr7182
Basinska, Teresa
Poland, Lodz
Institute - Center for Molecular and Macromolecular Studies of the Polish Academy of Sciences
Slomkowski, Stanislaw
Poland, Lodz
Institute - Center for Molecular and Macromolecular Studies of the Polish Academy of Sciences
Millot, Marie Claude
France, Thiais
Institut de Chimie et Des Matériaux de Paris Est Icmpe - Umr7182
Othmane, Ali
Tunisia, Monastir
Laboratoire de Biophysique - Tim
Ben Hassen-Chehimi, Dalila
Tunisia, Bizerte
Laboratoire D'application de la Chimie Aux Ressources et Substances Naturelles et a L'environnement
Chehimi, Mohamed Mehdi
France, Paris
Interfaces Traitements Organisation et Dynamique Des Systèmes – Itodys
Statistics
Citations: 66
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1021/la200290k
ISSN:
07437463
e-ISSN:
15205827
Research Areas
Environmental