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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antidiarrhoeal activity of the aqueous extract of Terminalia avicennoides roots
Phytotherapy Research, Volume 15, No. 5, Year 2001
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Description
The antidiarrhoeal effects of the aqueous root extract of Terminalia avicennoides were evaluated in rodents. Studies were carried out on the isolated rabbit jejunum, gastrointestinal motility in vivo and on castor oil-induced diarrhoea in mice. The results revealed that the extract exhibited a concentration-dependent inhibition of the spontaneous pendular movement of the isolated rabbit jejunum and attenuated acetylcholine induced contractions. The extract (100, 200 and 400 mg/kg) also caused a dose-dependent decrease of gastrointestinal transit and markedly protected mice against castor oil-induced diarrhoea. The intraperitoneal LD50 of the extract was found to be 871.4-917.4 mg/kg in mice (95 % confidence). A preliminary phytochemical screening of the aqueous extract of T. avicennoides roots revealed the presence of tannins, saponins and flavonoids. The results obtained showed that the water extract of T. avicennoides roots may contain some biologically active principles that may be active against diarrhoea and this may be the basis for its use traditionally for gastrointestinal disorders. Copyright © 2001 John Wiley & Sons, Ltd.
Authors & Co-Authors
Abdullahi, A. L.
Nigeria, Bauchi
Abubakar Tafawa Balewa University
Agho, Michael O.
Nigeria, Bauchi
Abubakar Tafawa Balewa University
Amos, S.
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Gamaniel, Karniyus Shingu
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Wambebe, Charles O.
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Statistics
Citations: 129
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1002/ptr.860
ISSN:
0951418X
Research Areas
Environmental
Infectious Diseases