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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
Nature Communications, Volume 2, No. 1, Article 601, Year 2011
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Description
Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induce robust protection in any clinical trial. Here we compare human-compatible viral-vectored vaccines targeting ten different blood-stage antigens. We show that the full-length P. falciparum reticulocyte-bindinGprotein homologue 5 (PfRH5) is highly susceptible to cross-strain neutralizing vaccine-induced antibodies, out-performing all other antigens delivered by the same vaccine platform. We find that, despite being susceptible to antibody, PfRH5 is unlikely to be under substantial immune selection pressure; there is minimal acquisition of anti-PfRH5 IgG antibodies in malaria-exposed Kenyans. These data challenge the widespread beliefs that any merozoite antigen that is highly susceptible to immune attack would be subject to significant levels of antigenic polymorphism, and that erythrocyte invasion by P. falciparum is a degenerate process involving a series of parallel redundant pathways. © 2011 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Douglas, Alexander D.
United Kingdom, Oxford
University of Oxford
Williams, Andrew R.
United Kingdom, Oxford
University of Oxford
Illingworth, Joseph J.
United Kingdom, Oxford
University of Oxford
Kamuyu, Gathoni
Kenya, Kilifi
Centre for Geographic Medicine Research
Biswas, Sumi
United Kingdom, Oxford
University of Oxford
Goodman, Anna L.
United Kingdom, Oxford
University of Oxford
Wyllie, David H.
United Kingdom, Oxford
University of Oxford
Crosnier, Cécile
United Kingdom, Hinxton
Wellcome Sanger Institute
Miura, Kazutoyo
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Wright, Gavin J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Long, Carole A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Osier, Faith Hope Among In
Kenya, Kilifi
Centre for Geographic Medicine Research
Marsh, Kevin
Kenya, Kilifi
Centre for Geographic Medicine Research
Turner, Alison V.
United Kingdom, Oxford
University of Oxford
Hill, Adrian V. S.
United Kingdom, Oxford
University of Oxford
Draper, Simon J.
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 630
Authors: 16
Affiliations: 4
Identifiers
Doi:
10.1038/ncomms1615
e-ISSN:
20411723
Research Areas
Infectious Diseases