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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1
PLoS Pathogens, Volume 9, No. 4, Article e1003315, Year 2013
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Description
The β-glucan receptor Dectin-1 is a member of the C-type lectin family and functions as an innate pattern recognition receptor in antifungal immunity. In both mouse and man, Dectin-1 has been found to play an essential role in controlling infections with Candida albicans, a normally commensal fungus in man which can cause superficial mucocutaneous infections as well as life-threatening invasive diseases. Here, using in vivo models of infection, we show that the requirement for Dectin-1 in the control of systemic Candida albicans infections is fungal strain-specific; a phenotype that only becomes apparent during infection and cannot be recapitulated in vitro. Transcript analysis revealed that this differential requirement for Dectin-1 is due to variable adaptation of C. albicans strains in vivo, and that this results in substantial differences in the composition and nature of their cell walls. In particular, we established that differences in the levels of cell-wall chitin influence the role of Dectin-1, and that these effects can be modulated by antifungal drug treatment. Our results therefore provide substantial new insights into the interaction between C. albicans and the immune system and have significant implications for our understanding of susceptibility and treatment of human infections with this pathogen. © 2013 Marakalala et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3630191/bin/ppat.1003315.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3630191/bin/ppat.1003315.s002.docx
Authors & Co-Authors
Marakalala, Mohlopheni Jackson
South Africa, Cape Town
University of Cape Town
United States, Cambridge
Harvard University
Vautier, Simon
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Potrykus, Joanna
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Walker, Louise A.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Shepardson, Kelly M.
United States, Hanover
Geisel School of Medicine at Dartmouth
Hopke, Alex
United States, Orono
University of Maine
Mora-Montes, Héctor Manuel
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Mexico, Guanajuato
Universidad de Guanajuato
Kerrigan, Ann M.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Murray, Graeme I.
United Kingdom, Aberdeen
University of Aberdeen
MacCallum, Donna M.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Wheeler, Robert
United States, Orono
University of Maine
Munro, Carol A.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Gow, Neil A.R.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Cramer, Robert A.
United States, Hanover
Geisel School of Medicine at Dartmouth
Brown, Alistair J.P.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Statistics
Citations: 170
Authors: 17
Affiliations: 8
Identifiers
Doi:
10.1371/journal.ppat.1003315
ISSN:
15537366
e-ISSN:
15537374