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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions
Carbohydrate Polymers, Volume 46, No. 1, Year 2001
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Description
In this study we demonstrate that chitosan solutions can be neutralised up to physiological pH (∼7.2) using β-glycerol phosphate without creating immediate gel-like precipitation and furthermore that subsequent heating of these solutions induces hydrogel formation. The addition of the particular basic salt, glycerol phosphate, provides the correct buffering and other physicochemical conditions including control of hydrophobic interactions and hydrogen bonding which are necessary to retain chitosan in solution at neutral pH near 4°C and furthermore to allow gel formation upon heating to 37°C. Rheological investigation evidenced the endothermic gelation of chitosan/β-glycerol phosphate solutions and allowed the establishment of a sol/gel diagram. The gelation process appears to be governed by delicate interplay between the pH and the temperature. The role of β-glycerol phosphate is discussed in the light of relevant literature particularly those indicating the role of glycerol and polyols in the stabilisation of proteins and polysaccharides. © 2001 Elsevier Science Ltd.
Authors & Co-Authors
Chénite, Abdellatif
Canada, Laval
Biosyntech
Buschmann, Michael D.
Canada, Montreal
Polytechnique Montréal
Wang, D.
Canada, Laval
Biosyntech
Chaput, C.
Canada, Laval
Biosyntech
Kandani, N.
Morocco, Marakech
Faculté Des Sciences Semlalia
Statistics
Citations: 462
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/S0144-8617(00)00281-2
ISSN:
01448617