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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
Nature, Volume 480, No. 7378, Year 2011
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Description
Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion requires a series of extracellular recognition events between erythrocyte receptors and ligands on the merozoite, the invasive form of the parasite. None of the few known receptor-ligand interactions involved are required in all parasite strains, indicating that the parasite is able to access multiple redundant invasion pathways. Here, we show that we have identified a receptor-ligand pair that is essential for erythrocyte invasion in all tested P. falciparum strains. By systematically screening a library of erythrocyte proteins, we have found that the Ok blood group antigen, basigin, is a receptor for PfRh5, a parasite ligand that is essential for blood stage growth. Erythrocyte invasion was potently inhibited by soluble basigin or by basigin knockdown, and invasion could be completely blocked using low concentrations of anti-basigin antibodies; importantly, these effects were observed across all laboratory-adapted and field strains tested. Furthermore, Ok a- erythrocytes, which express a basigin variant that has a weaker binding affinity for PfRh5, had reduced invasion efficiencies. Our discovery of a cross-strain dependency on a single extracellular receptor-ligand pair for erythrocyte invasion by P. falciparum provides a focus for new anti-malarial therapies. © 2011 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Crosnier, Cécile
United Kingdom, Hinxton
Wellcome Sanger Institute
Bustamante, Leyla Y.
United Kingdom, Hinxton
Wellcome Sanger Institute
Bartholdson, S. Josefin
United Kingdom, Hinxton
Wellcome Sanger Institute
Bei, Amy Kristine
United States, Boston
Harvard T.h. Chan School of Public Health
Theron, Michel
United Kingdom, Hinxton
Wellcome Sanger Institute
Uchikawa, Makoto
Japan, Tokyo
Japanese Red Cross Tokyo Blood Center
Mboup, Souleymane
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Ndir, Oumar
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Kwiatkowski, Dominic P.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Duraisingh, Manoj Theodore
United States, Boston
Harvard T.h. Chan School of Public Health
Rayner, Julian C.
United Kingdom, Hinxton
Wellcome Sanger Institute
Wright, Gavin J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Statistics
Citations: 606
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1038/nature10606
ISSN:
00280836
e-ISSN:
14764687
Research Areas
Health System And Policy
Infectious Diseases