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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains
Nature Communications, Volume 5, Article 4052, Year 2014
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Description
Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (∼92%) and easily adapted to aid case management in the field and survey parasite migration worldwide. © 2014 Macmillan Publishers Limited. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4082634/bin/ncomms5052-s1.pdf
Authors & Co-Authors
Preston, Mark D.
Unknown Affiliation
Campino, Susana G.
Unknown Affiliation
Assefa, Samuel
Unknown Affiliation
Echeverry, Diego Fernando
Unknown Affiliation
Ocholla, Harold
Unknown Affiliation
Amambua-Ngwa, Alfred
Unknown Affiliation
Stewart, Lindsay B.
Unknown Affiliation
Conway, David J.
Unknown Affiliation
Borrmann, Steffen
Unknown Affiliation
Michon, Pascal A.
Unknown Affiliation
Zongo, Issaka D.
Unknown Affiliation
Ouedraogo, Jean Bosco
Unknown Affiliation
Djimde, Abdoulaye A.
Unknown Affiliation
Doumbo, Ogobara K.
Unknown Affiliation
Nosten, François Henry
Unknown Affiliation
Pain, Arnab P.
Unknown Affiliation
Bousema, Teun
Unknown Affiliation
Drakeley, Chris J.
Unknown Affiliation
Fairhurst, Rick M.
Unknown Affiliation
Sutherland, Colin J.
Unknown Affiliation
Roper, Cally
Unknown Affiliation
Clark, Taane Gregory
Unknown Affiliation
Statistics
Citations: 119
Authors: 22
Affiliations: 17
Identifiers
Doi:
10.1038/ncomms5052
e-ISSN:
20411723
Research Areas
Environmental
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative