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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Proton-induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development
Nuclear Medicine and Biology, Volume 50, Year 2017
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Description
Scandium-44 g (half-life 3.97 h) shows promise for application in positron emission tomography (PET), due to favorable decay parameters. One of the sources of 44gSc is the 44Ti/44gSc generator, which can conveniently provide this radioisotope on a daily basis at a diagnostic facility. Titanium-44 (half-life 60.0 a), in turn, can be obtained via proton irradiation of scandium metal targets. A substantial 44Ti product batch, however, requires high beam currents, long irradiation times and an elaborate chemical procedure for 44Ti isolation and purification. This study describes the production of a combined 175 MBq (4.7 mCi) batch yield of 44Ti in week long proton irradiations at the Los Alamos Isotope Production Facility (LANL-IPF) and the Brookhaven Linac Isotope Producer (BNL-BLIP). A two-step ion exchange chromatography based chemical separation method is introduced: first, a coarse separation of 44Ti via anion exchange sorption in concentrated HCl results in a 44Tc/Sc separation factor of 102–103. A second, cation exchange based step in HCl media is then applied for 44Ti fine purification from residual Sc mass. In summary, this method yields a 90–97% 44Ti recovery with an overall Ti/Sc separation factor of ≥106. © 2017 Elsevier Inc.
Authors & Co-Authors
Radchenko, Valery I.
United States, Los Alamos
Los Alamos National Laboratory
Engle, Jonathan W.
United States, Los Alamos
Los Alamos National Laboratory
Mausner, Leonard F.
United States, Upton
Brookhaven National Laboratory
Cutler, Cathy Sue
United States, Upton
Brookhaven National Laboratory
Nortier, Francois Meiring
United States, Los Alamos
Los Alamos National Laboratory
Fassbender, Michael E.
United States, Los Alamos
Los Alamos National Laboratory
Statistics
Citations: 26
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.nucmedbio.2017.03.006
ISSN:
09698051
Research Areas
Environmental
Health System And Policy