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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: A double blind, randomized trial
Asian Journal of Andrology, Volume 7, No. 3, Year 2005
Notification
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Description
Aim: To evaluate the treatment of male infertility with a strong natural antioxidant, in addition to conventional treatment. Methods: Using a double blind, randomized trial design, 30 men with infertility of ≥12 months and female partners with no demonstrable cause of infertility received conventional treatment according to the guidelines of the World Health Organization (WHO), and either a strong antioxidant Astaxanthin 16 mg/day (AstaCarox®, AstaReal AB, Gustavsberg, Sweden) or placebo for 3 months. The effects of treatment on semen parameters, reactive oxygen species (ROS), zona-free hamster oocyte test, serum hormones including testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and Inhibin B, and spontaneous or intrauterine insemination (IUI)-induced pregnancies were evaluated. Results: ROS and Inhibin B decreased significantly and sperm linear velocity increased in the Astaxanthin group (n = 11), but not in the placebo group (n = 19). The results of the zona-free hamster oocyte test tended to improve in the Astaxanthin group in contrast with the placebo group, though not reaching statistical significance. The total and per cycle pregnancy rates among the placebo cases (10.5% and 3.6%) were lower compared with 54.5% and 23.1% respectively in the Astaxanthin group (P = 0.028; P = 0.036). Conclusion: Although the present study suggests a positive effect of Astaxanthin on sperm parameters and fertility, the results need to be confirmed in a larger trial before recommending Astaxanthin for the complementary treatment of infertile men. © 2005, Asian Journal of Andrology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences. All rights reserved.
Authors & Co-Authors
Comhaire, Frankc H.
Belgium, Ghent
Universitair Ziekenhuis Gent
El Garem, Yehia
Egypt, Alexandria
Alexandria University Hospitals
Mahmoud, Ahmed M.A.
Belgium, Ghent
Universitair Ziekenhuis Gent
Eertmans, F.
Belgium, Ghent
Universitair Ziekenhuis Gent
Schoonjans, Frank A.
Belgium, Ghent
Universitair Ziekenhuis Gent
Statistics
Citations: 180
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1745-7262.2005.00047.x
ISSN:
1008682X
Research Areas
Disability
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Male
Female