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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Adipokines in umbilical cord blood from children born large for gestational age
Journal of Pediatric Endocrinology and Metabolism, Volume 29, No. 1, Year 2016
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Description
Background: The etiology of childhood obesity and the associated morbidity is multifactorial. Recently, data suggesting a prenatal programming towards later childhood obesity and metabolic deregulation through the intrauterine environment has emerged. This study explored the concentrations of adipokines and their mutual relationship at birth in children born to non-diabetic mothers. Methods: Adiponectin, leptin and sOB-R were measured using ELISA-based commercial kits in umbilical cord blood from 60 neonates (30 born large for gestational age [LGA] and 30 born appropriate for gestational age [AGA]). Children exposed to maternal diabetes, chronic disease and preeclampsia were excluded. Results: The LGA group exhibited significantly elevated concentrations of leptin (p<0.001) and of free leptin index (p<0.001) and decreased sOB-R concentrations (p=0.005) when compared to the AGA group, which persisted in multiple regression analysis after taking the gestational age into account (p=0.048, p<0.001 and p<0.001, respectively). Only a trend towards a difference in adiponectin was demonstrated (p=0.057) regardless of adjustment (p=0.150). However, the leptin/adiponectin ratio was elevated in the LGA group (p=0.008), regardless of adjustment (p=0.039). Conclusion: The data indicate a disturbance of adipokines in macrosomic newborns and that the mutual ratios between adipokines may provide a more sensitive marker of metabolic disturbance than any isolated adipokine. © 2016 by De Gruyter.
Authors & Co-Authors
Lausten-Thomsen, Ulrik
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Christiansen, Michael
Denmark, Copenhagen
Statens Serum Institut
Hedley, P. L.
Denmark, Copenhagen
Statens Serum Institut
Holm, Jens Christian
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Schmiegelow, Kjeld
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Statistics
Citations: 17
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1515/jpem-2014-0502
ISSN:
0334018X
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Approach
Quantitative