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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation
Journal of Leukocyte Biology, Volume 77, No. 3, Year 2005
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Description
Molecular markers, especially surface markers associated with type II, cytokine-dependent, alternatively activated macrophages (aaMF), remain scarce. Besides the earlier documented markers, macrophage mannose receptor and arginase 1, we demonstrated recently that murine aaMF are characterized by increased expression of found in inflammatory zone 1 (FIZZ1) and the secretory lectin Ym. We now document that expression of the two members of the mouse macrophage galactose-type C-type lectin gene family (mMGL1 and mMGL2) is induced in diverse populations of aaMF, including peritoneal macrophages elicited during infection with the protozoan Trypanosoma brucei brucei or the Helminth Taenia crassiceps and alveolar macrophages elicited in a mouse model of allergic asthma. In addition, we demonstrate that in vitro, interleukin-4 (IL-4) and IL-13 up-regulate mMGL1 and mMGL2 expression and that in vivo, induction of mMGL1 and mMGL2 is dependent on IL-4 receptor signaling. Moreover, we show that expression of MGL on human monocytes is also up-regulated by IL-4. Hence, macrophage galactose-type C-type lectins represent novel surface markers for murine and human aaMF. © Society for Leukocyte Biology.
Authors & Co-Authors
Raes, Geert
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Brys, Lea
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Dahal, Bhola Kumar
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Brandt, Jozef R.A.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Grooten, Johan
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Brombacher, Frank
South Africa, Observatory
Groote Schuur Hospital
Vanham, Guido L.E.E.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Noël, Wim
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Bogaert, Pieter
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Boonefaes, Tom
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Kindt, Anne
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Van den Bergh, Rafael
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Leenen, Pieter Johannes Maria
Netherlands, Rotterdam
Erasmus Mc
de Baetseĺier, Patrick C.
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Ghassabeh, Gholamreza Hassanzadeh
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Statistics
Citations: 255
Authors: 15
Affiliations: 4
Identifiers
Doi:
10.1189/jlb.0304212
Research Areas
Genetics And Genomics