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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load
Journal of Virology, Volume 79, No. 16, Year 2005
Notification
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Description
Several HLA class I alleles have been associated with slow human immunodeficiency virus (HIV) disease progression, supporting the important role HLA class I-restricted cytotoxic T lymphocytes (CTL) play in controlling HIV infection. HLA-B63, the serological marker for the closely related HLA-BH516 and HLA-B*1517 alleles, shares the epitope binding motif of HLA-B57 and HLA-B58, two alleles that have been associated with slow HIV disease progression. We investigated whether HIV-infected individuals who express HLA-B63 generate CTL responses that are comparable in breadth and specificity to those of HLA-B57/58-positive subjects and whether HLA-B63-positive individuals would also present with lower viral set points than the general population. The data show that HLA-B63-positive individuals indeed mounted responses to previously identified HLA-B57-restricted epitopes as well as towards novel, HLA-B63-restricted CTL targets that, in turn, can be presented by HLA-B57 and HLA-B58. HLA-B63-positive subjects generated these responses early in acute HIV infection and were able to control HIV replication in the absence of antiretroviral treatment with a median viral load of 3,280 RNA copies/ml. The data support an important role of the presented epitope in mediating relative control of HIV replication and help to better define immune correlates of controlled HIV infection. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Frahm, Nicole
United States, Boston
Massachusetts General Hospital
Adams, Sharon D.
United States, Bethesda
Nih Clinical Center Cc
Kiepiela, Photini
South Africa, Durban
University of Kwazulu-natal
Linde, Caitlyn H.
United States, Boston
Massachusetts General Hospital
Hewitt, Hannah S.
United States, Boston
Massachusetts General Hospital
Lichterfeld, Mathias D.
United States, Boston
Massachusetts General Hospital
Sango, Kaori
United States, Boston
Massachusetts General Hospital
Brown, Nancy V.
United States, Boston
Massachusetts General Hospital
Pae, Eunice
United States, Boston
Fenway Community Health Center
Wurcel, Alysse Gail
United States, Boston
Lemuel Shattuck Hospital
Altfeld, Marcus A.
United States, Boston
Massachusetts General Hospital
Feeney, Margaret E.
United States, Boston
Massachusetts General Hospital
Allen, Todd M.
United States, Boston
Massachusetts General Hospital
Roach, Timothy C.
Barbados, Bridgetown
Queen Elizabeth Hospital Bridgetown
St.John, M. Anne
Barbados, Bridgetown
Queen Elizabeth Hospital Bridgetown
Daar, Eric S.
United States, Torrance
Harbor-ucla Medical Center
Rosenberg, Eric S.
United States, Boston
Massachusetts General Hospital
Korber, Bette T.
United States, Los Alamos
Los Alamos National Laboratory
United States, Santa fe
Santa fe Institute
Marincola, Franco Maria
United States, Bethesda
Nih Clinical Center Cc
Walker, Bruce D.
United States, Boston
Massachusetts General Hospital
Goulder, Philip Jeremy Renshaw
United States, Boston
Massachusetts General Hospital
Brander, Christian
United States, Boston
Massachusetts General Hospital
Statistics
Citations: 79
Authors: 22
Affiliations: 9
Identifiers
Doi:
10.1128/JVI.79.16.10218-10225.2005
ISSN:
0022538X
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study