Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in Burkina Faso: Contribution for their preservation
Parasitology Research, Volume 106, No. 2, Year 2010
Notification
URL copied to clipboard!
Description
In order to prevent the destruction of the ecology and to sustain the flora mainly for medicinal plants, we investigated on alternative parts taken from four plants already known to display antiplasmodial activities and largely used by traditional healers in sub-Saharan Africa. The evaluated parts are bark of trunk for Zanthoxylum zanthoxyloides and leaves for Sarcocephalus latifolius instead of roots, and leaves for Combretum molle and Anogeissus leiocarpus instead of stem bark. The antiplasmodial activity of extracts of these plants was evaluated in vitro using the multi-resistant strain (W2) of Plasmodium falciparum. Antiproliferative activity was also assessed, using K562S human monocyte cell lines, along with calculation of the selectivity index (SI) of each extract. The highest in vitro antiplasmodial activity was found in the alkaloid extract of trunk bark from Z. zanthoxyloides and from the MeOH extract of A. leiocarpus leaves (IC50= 1.2 μg/mL and 4.9 μg/mL, respectively) with good selectivity index. Moderate activity was found in the MeOH extract (IC50=5.7 μg/mL) and MeOH/H2O extract (IC 50=7.9 μg/mL) of C. molle leaves. Moderate activity was also found in the MeOH/H20 extract (IC50=5.2 μg/mL) and the decoction (IC50=8.2 μg/mL) from leaves of A. leiocarpus. No good activity was found with extracts from roots of S. latifolius. All extracts tested displayed low levels of cytotoxicity against K562S cells. The data generated clearly show that the trunk bark for Z. zanthoxyloides and the leaves for A. leiocarpus and C. molle could be used for the treatment of malaria instead of roots and stem bark. © Springer-Verlag 2009.
Authors & Co-Authors
Gansané, Adama
Brunei Darussalam, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Sanon, Souleymane
Brunei Darussalam, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Ouattara, Lamoussa Paul
Brunei Darussalam, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Traoré, Abdoulaye Mamadou
Brunei Darussalam, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Hutter, Sébastien
France, Marseille
Aix Marseille Université
Ollivier, Évelyne
France, Marseille
Aix Marseille Université
Azas, Nadine
France, Marseille
Aix Marseille Université
Traoré, Alfred Sababénédjo
Burkina Faso, Ouagadougou
Université Joseph Ki-zerbo
Guissou, Innocent Pierre
Burkina Faso, Ouagadougou
Université Joseph Ki-zerbo
Sirima, Sodiomon Bienvenu
Brunei Darussalam, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Brunei Darussalam, Ouagadougou
Groupe de Recherche et D'action en Santé Gras
Nèbiè, Issa O.
Brunei Darussalam, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Statistics
Citations: 57
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1007/s00436-009-1663-y
ISSN:
09320113
Research Areas
Infectious Diseases
Study Locations
Burkina Faso