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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
Malaria Journal, Volume 7, Article 174, Year 2008
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Description
Background. Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa. Methods. Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries. Results. Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa. Conclusion. The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers. © 2008 Culleton et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Culleton, Richard Leighton
Japan, Suita
Research Institute for Microbial Diseases
Japan, Nagasaki
Nagasaki University
Mita, T.
Japan, Tokyo
Tokyo Women's Medical University
Ndounga, Mathieu
Congo
Centre D'etudes Des Resources Vegetales
Unger, Holger Werner
United Kingdom, Edinburgh
The University of Edinburgh
Cravo, Pedro Vítor Lemos
Portugal, Lisbon
Centro de Malária e Outras Doenças Tropicais/ihmt e Hospital Egas Moniz
Paganotti, Giacomo Maria
Italy, Rome
Sapienza Università Di Roma
Takahashi, Nobuyuki
Japan, Tokyo
Tokyo Women's Medical University
Kaneko, Akira
Sweden, Stockholm
Karolinska Universitetssjukhuset
Eto, Hideaki
Japan, Tokyo
Tokyo Women's Medical University
Tinto, Halidou
Burkina Faso, Ouagadougou
Centre Muraz
Karema, Corine Kakizi
Rwanda, Kigali
Programme National Intégré de Lutte Contre le Paludisme
D'Alessandro, Umberto
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
do Rosário, Virgílio Estólio
Portugal, Lisbon
Centro de Malária e Outras Doenças Tropicais/ihmt e Hospital Egas Moniz
Kobayakawa, Takatoshi
Japan, Tokyo
Tokyo Women's Medical University
Ntoumi, Francine
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Carter, Richard
United Kingdom, Edinburgh
The University of Edinburgh
Tanabe, Kazuyuki
Japan, Suita
Research Institute for Microbial Diseases
Statistics
Citations: 88
Authors: 17
Affiliations: 12
Identifiers
Doi:
10.1186/1475-2875-7-174
e-ISSN:
14752875
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Sao Tome and Principe