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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Bilistick: A low-cost point-of-care system to measure total plasma bilirubin
Neonatology, Volume 103, No. 3, Year 2013
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Description
Background: Severe neonatal hyperbilirubinemia, with consequent encephalopathy, remains a common cause of morbidity and death in many regions of the world. Poor access to clinical laboratory resources and screening programs to measure plasma bilirubin levels is a major contributor to delayed treatment in developing countries, and the cost of existing point-of-care screening instruments precludes their dissemination. Objectives: We are evaluating the accuracy of a low-cost, minimally invasive point-of-care system (Bilistick) requiring a 25-μl blood sample that could be used in low-resource environments to evaluate patients with neonatal jaundice. Methods: We compared plasma bilirubin levels in divided blood samples by clinical laboratories and by Bilistick at two medical centers serving term and near-term newborns from ethnically different populations. Results: 118 neonates with bilirubin levels ranging from 24.8 to 501.0 μmol/l were analyzed. The mean bilirubin concentration (±SD) was 215.6 ± 85.5 μmol/l for Bilistick and 226.1 ± 86.4 μmol/l by laboratory determination. Pearson's correlation coefficient between all paired results was 0.961, and the Bland-Altman analysis showed a mean difference of 10.3 μmol/l with a 95% interval of agreement of -38.0 to 58.7 μmol/l. Conclusion: Bilistick is a minimally invasive method for measuring total bilirubin concentration over a wide range of values and should provide an affordable and accurate system for pre-discharge and follow-up screening of jaundiced infants, particularly in low-resource environments. Copyright © 2012 S. Karger AG, Basel.
Authors & Co-Authors
Zabetta, Carlos D.Coda
Italy, Trieste
Italian Liver Foundation
Iskander, Iman Fathi
Egypt, Cairo
Faculty of Medicine
Greco, C.
Italy, Trieste
Italian Liver Foundation
Bellarosa, C.
Italy, Trieste
Italian Liver Foundation
Demarini, S.
Italy, Trieste
Irccs Burlo Garofolo
Tiribelli, Claudio
Italy, Trieste
Italian Liver Foundation
Italy, Trieste
Università Degli Studi Di Trieste
Wennberg, Richard P.
Italy, Trieste
Italian Liver Foundation
Statistics
Citations: 50
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1159/000345425
e-ISSN:
16617819
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study