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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Tinea corporis/cruris: New treatment options
Dermatology, Volume 194, No. 1, Year 1997
Notification
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Description
We undertook a prospective, multicentre, double-blind, placebo controlled, randomised, parallel-group study to evaluate the efficacy and safety of the topical 1% emulsion gel formulation of Lamisil◇ in the treatment of tinea corporis/cruris. Eighty-three patients with clinically and mycologically confirmed tinea corporis/cruris were enrolled from 6 dermatology practices. Of the 62 patients in the intent-to-treat population, 29 were randomised to 1% Lamisil emulsion gel (23 male, 6 female; mean age 42 years, range 19–79 years) and 33 to placebo (25 male, 8 female; mean age 36 years, range 16–73 years). The gels were applied once daily for 1 week. Mycological cure (negative microscopy and culture results) and effectiveness of treatment (mycological cure plus no or minimal signs and symptoms) were measured on day 7, weeks 2, 4 and 8, and at the end of the study. At the study end, rates of mycological cure were 83% for Lamisil 1% emulsion gel and 27% for placebo gel (p < 0.001), with respective rates for effective treatment of 83 and 21% (p < 0.001). Complete cure was recorded for 59% of patients receiving Lamisil 1% emulsion gel and 13% of patients receiving placebo gel (p < 0.001). We conclude that a 1-week course of Lamisil 1% emulsion gel is significantly more effective in the treatment of tinea corporis/cruris than placebo gel in respect of complete cure, mycological cure and effective treatment. © 1997 S.Karger AG, Basel.
Authors & Co-Authors
Van Heerden, J. S.
South Africa, Pretoria
Private Practice
Vismer, Hester Francis
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 15
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1159/000246177
ISSN:
10188665
e-ISSN:
14219832
Research Areas
Disability
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female