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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The combined effect of radiofrequency and ethanol ablation in the management of large hepatocellular carcinoma
European Journal of Radiology, Volume 54, No. 3, Year 2005
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Description
Only a small percentage of patients with large hepatocellular carcinoma (HCC) may benefit out of surgical resection. Thus, most of these patients are in need of a form of local control, such as ethanol ablation, transarterial chemoembolization (TACE), radiofrequency thermal ablation (RF), or laser induced thermotherapy (LITT). The purpose of this study was to assess the short-term effect of sequential RF and ethanol ablation in the management of large HCC (>5 cm). Our series included 40 patients with large HCC tumors (>5 cm in diameter). We adopted a protocol of overlapping RF applications, followed by repeated ethanol ablation sessions. Our results showed that the volume of tumor coagulative necrosis initially induced by RF has significantly risen after adjuvant ethanol ablation sessions (P < 0.001). Patients who achieved complete tumor necrosis after RF ablation were 52.5% of the series. This percent has jumped to 80% of the series at the end of the protocol. This indicates that such combined protocol is more effective than RF alone. Besides, it is valuable in reducing the number of RF sessions. © 2004 Published by Elsevier Ireland Ltd.
Authors & Co-Authors
Sakr, Ayman A.
Egypt, Alexandria
Alexandria University
Saudi Arabia, Al-khobar
Almana General Hospital
Saleh, Alaa Ahmed
Egypt, Alexandria
Alexandria University
Moeaty, Amr Ali Abdel
Egypt, Alexandria
Faculty of Medicine
Moeaty, Ali Abdel
Egypt, Alexandria
Faculty of Medicine
Statistics
Citations: 12
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejrad.2004.06.008
ISSN:
0720048X
Research Areas
Cancer
Health System And Policy