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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Nature Genetics, Volume 41, No. 12, Year 2009
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Description
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the gene encoding α-synuclein (SNCA; rs2736990, OR = 1.23, P = 2.24 × 10 16) and another at the MAPT locus (rs393152, OR = 0.77, P = 1.95 × 10 16). We exchanged data with colleagues performing a GWAS in Japanese PD cases. Association to PD at SNCA was replicated in the Japanese GWAS, confirming this as a major risk locus across populations. We replicated the effect of a new locus detected in the Japanese cohort (PARK16, rs823128, OR = 0.66, P = 7.29 × 10 8) and provide supporting evidence that common variation around LRRK2 modulates risk for PD (rs1491923, OR = 1.14, P = 1.55 × 10 5). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease. © 2009 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Simón-Sánchez, Javier
United States, Bethesda
National Institutes of Health Nih
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Schulte, Claudia M.S.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Brás, José Miguel
United States, Bethesda
National Institutes of Health Nih
Portugal, Coimbra
Universidade de Coimbra
Sharma, Manu
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gibbs, J. Raphael
United States, Bethesda
National Institutes of Health Nih
United Kingdom, London
Ucl Queen Square Institute of Neurology
Berg, Daniela
Germany, Tubingen
Eberhard Karls Universität Tübingen
Lichtner, Peter K.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Scholz, Sonja W.
United States, Bethesda
National Institutes of Health Nih
United Kingdom, London
Ucl Queen Square Institute of Neurology
Hernandez, Dena G.
United States, Bethesda
National Institutes of Health Nih
United Kingdom, London
Ucl Queen Square Institute of Neurology
Krüger, Rejko
Germany, Tubingen
Eberhard Karls Universität Tübingen
Federoff, Monica
United States, Bethesda
National Institutes of Health Nih
Klein, Christine
Germany, Lubeck
Universität zu Lübeck
Perlmutter, Joel S.
United States, St. Louis
Washington University School of Medicine in St. Louis
Bonin, Michael
Germany, Tubingen
Eberhard Karls Universität Tübingen
Nalls, Mike A.
United States, Bethesda
National Institutes of Health Nih
Illig, Thomas
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Gieger, Christian
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Houlden, Henry H.
United Kingdom, London
Ucl Queen Square Institute of Neurology
Steffens, Michael
Germany, Bonn
Universität Bonn
Racette, Brad A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Cookson, Mark Robert
United States, Bethesda
National Institutes of Health Nih
Fernandez, Hubert H.
United States, Gainesville
University of Florida
Traynor, B. J.
United States, Bethesda
National Institutes of Health Nih
Schreiber, Stefan W.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Arepalli, Sampath K.
United States, Bethesda
National Institutes of Health Nih
Gwinn-Hardy, Katrina A.
United States, Houston
Baylor College of Medicine
Chanock, Stephen J.
United States, Rockville
National Cancer Institute Nci
Park, Yikyung
United States, Rockville
National Cancer Institute Nci
Gao, Jianjun
United States, Bethesda
National Institutes of Health Nih
Wood, Nick William
United Kingdom, London
Ucl Queen Square Institute of Neurology
Lorenz, Delia
Germany, Kiel
Christian-albrechts-universität zu Kiel
Deuschl, Günther D.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Chen, Honglei
United States, Bethesda
National Institutes of Health Nih
Rivadeneira, F.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Hardy, John A.
United Kingdom, London
Ucl Queen Square Institute of Neurology
Singleton, Andrew B.
United States, Bethesda
National Institutes of Health Nih
Gasser, Thomas G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 1,527
Authors: 37
Affiliations: 15
Identifiers
Doi:
10.1038/ng.487
ISSN:
10614036
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study