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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Meanderella rijsii, a new opportunist in the fungal order Pleosporales
Microbes and Infection, Volume 24, No. 4, Article 104932, Year 2022
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Description
Subcutaneous phaeohyphomycosis is an implantation disease caused by melanized fungi and affect both immunocompetent as well as immunocompromised individuals. Diagnosis and treatment require proper isolation and accurate identification of the causative pathogen. We isolated a novel fungus from a case of subcutaneous phaeohyphomycosis in an immunocompetent patient. The 56-year-old patient suffered from a slowly progressive swelling on the metatarsophalangeal join of the left food. The isolated fungus lacked sporulation and sequences of the ribosomal operon did not match with any known species. In a multi-locus phylogenetic analysis involving five markers, the fungus formed a unique lineage in the order Pleosporales, family Trematosphaeriaceae. A new genus, Meanderella and a new species, Meanderella rijsii are here proposed to accommodate the clinical isolate. Whole genome analysis of M. rijsii revealed a number of genes that can be linked to pathogenicity and virulence. Further studies are however needed to understand the role of each gene in the pathogenic process and to determine the origin of pathogenicity in the family of Trematosphaeriaceae. © 2022 The Author(s)
Authors & Co-Authors
Ahmed, Sarah A.
Netherlands, Nijmegen
Radboud University Medical Center
Netherlands, Hilversum
Foundation Atlas of Clinical Fungi
Godschalk, Peggy C.R.
Netherlands, Amersfoort
Meander Medical Center
Moreno, Leandro Ferreira
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van der Lee, Henrich A.L.
Netherlands, Nijmegen
Radboud University Medical Center
Verweij, Paul E.
Netherlands, Nijmegen
Radboud University Medical Center
de Hoog, Sybren
Netherlands, Nijmegen
Radboud University Medical Center
Netherlands, Hilversum
Foundation Atlas of Clinical Fungi
China, Beijing
Ministry of Education of the People's Republic of China
Statistics
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1016/j.micinf.2022.104932
ISSN:
12864579
Research Areas
Food Security
Genetics And Genomics
Health System And Policy