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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association of pulmonary tuberculosis with increased dietary iron
Journal of Infectious Diseases, Volume 184, No. 7, Year 2001
Notification
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Description
To determine whether increased dietary iron could be a risk factor for active tuberculosis, dietary iron history and human immunodeficiency virus (HIV) status were studied in 98 patients with pulmonary tuberculosis and in 98 control subjects from rural Zimbabwe. Exposure to high levels of dietary iron in the form of traditional beer is associated with increased iron stores in rural Africans. HIV seropositivity was associated with a 17.3-fold increase in the estimated odds of developing active tuberculosis (95% confidence interval [95% CI], 7.4-40.6; P < .001), and increased dietary iron was associated with a 3.5-fold increase (95% CI, 1.4-8.9; P = .009). Among patients treated for tuberculosis, HIV seropositivity was associated with a 3.8-fold increase in the estimated hazard ratio of death (95% CI, 1.0-13.8; P = .046), and increased dietary iron was associated with a 1.3-fold increase (95% CI, 0.4-6.4; P = .2). These findings are consistent with the hypothesis that elevated dietary iron may increase the risk of active pulmonary tuberculosis. © 2001 by the Infectious Diseases Society of America.
Authors & Co-Authors
Gangaidzo, Innocent Tichaona
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Moyo, Victor M.
United States, Baltimore
The Sidney Kimmel Comprehensive Cancer Center
Mvundura, Elisha
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Aggrey, George
United States, Washington, D.c.
George Washington University Medical Center
Murphree, Nyasha L.
Zimbabwe
Nyadire Mission Hospital
Khumalo, Hlosukwazi
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Saungweme, Thokozile
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Kasvosve, Ishmael
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Gomo, Zvenyika Alfred R.
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Rouault, Tracey Ann
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Boelaert, Johan R.O.
Belgium, Brugge
General Hospital St. Jan
Gordeuk, Victor R.
United States, Washington, D.c.
The Center for Sickle Cell Disease
Statistics
Citations: 190
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1086/323203
ISSN:
00221899
Research Areas
Environmental
Infectious Diseases
Study Locations
Zimbabwe