Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Divergence and recombination of clinical herpes simplex virus type 2 isolates
Journal of Virology, Volume 81, No. 23, Year 2007
Notification
URL copied to clipboard!
Description
Herpes simplex virus type 2 (HSV-2) infects the genital mucosa and is one of the most common sexually transmitted viruses. Here we sequenced a segment comprising 3.5% of the HSV-2 genome, including genes coding for glycoproteins G, I, and E, from 27 clinical isolates from Tanzania, 10 isolates from Norway, and 10 isolates from Sweden. The sequence variation was low compared to that described for clinical HSV-1 isolates, with an overall similarity of 99.6% between the two most distant HSV-2 isolates. Phylogenetic analysis revealed a divergence into at least two genogroups arbitrarily designated A and B, supported by high bootstrap values and evolutionarily separated at the root. Genogroup A contained isolates collected in Tanzania, and genogroup B contained isolates collected in Tanzania and Scandinavia, implying that the genetic variability of HSV-2 is higher in Tanzania than in Scandinavia. Recombination network analysis and bootscan analysis revealed a complex pattern of phylogenetically conflicting informative sites in the sequence alignments. These signals were present in synonymous and nonsynonymous sites in all three genes and were not accumulated in specific regions, observations arguing against positive selection. Since the PHI test applied solely to synonymous sites revealed a high statistical probability of recombination, we suggest as a novel finding that homologous recombination is, as reported earlier for HSV-1 and varicella-zoster virus, a prominent feature in the evolution of HSV-2. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Norberg, Peter
Sweden, Gothenburg
Göteborgs Universitet
Kasubi, Mabula Joseph
Norway, Bergen
Universitetet I Bergen
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Haarr, Lars
Norway, Bergen
Universitetet I Bergen
Bergström, Tomas B.
Sweden, Gothenburg
Göteborgs Universitet
Liljeqvist, Jan Åke
Sweden, Gothenburg
Göteborgs Universitet
Statistics
Citations: 70
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1128/JVI.01310-07
ISSN:
0022538X
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Study Locations
Tanzania