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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients
PLoS ONE, Volume 8, No. 1, Article e54793, Year 2013
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Description
Background: Genetic variation in the IL28B gene has been strongly associated with treatment outcomes, spontaneous clearance and progression of the hepatitis C virus infection (HCV). The aim of the present study was to investigate the role of polymorphisms at this locus with progression and outcome of HCV infection in a Moroccan population. Methods: We analyzed a cohort of 438 individuals among them 232 patients with persistent HCV infection, of whom 115 patients had mild chronic hepatitis and 117 had advanced liver disease (cirrhosis and hepatocellular carcinoma), 68 individuals who had naturally cleared HCV and 138 healthy subjects. The IL28B SNPs rs12979860 and rs8099917 were genotyped using a TaqMan 5′ allelic discrimination assay. Results: The protective rs12979860-C and rs8099917-T alleles were more common in subjects with spontaneous clearance (77.9% vs 55.2%; p = 0.00001 and 95.6% vs 83.2%; p = 0.0025, respectively). Individuals with clearance were 4.69 (95% CI, 1.99-11.07) times more likely to have the C/C genotype for rs12979860 polymorphism (p = 0.0017) and 3.55 (95% CI, 0.19-66.89) times more likely to have the T/T genotype at rs8099917. Patients with advanced liver disease carried the rs12979860-T/T genotype more frequently than patients with mild chronic hepatitis C (OR = 1.89; 95% CI, 0.99-3.61; p = 0.0532) and this risk was even more pronounced when we compared them with healthy controls (OR = 4.27; 95% CI, 2.08-8.76; p = 0.0005). The rs8099917-G allele was also associated with advanced liver disease (OR = 2.34; 95% CI, 1.40-3.93; p = 0.0100). Conclusions: In the Moroccan population, polymorphisms near the IL28B gene play a role both in spontaneous clearance and progression of HCV infection. © 2013 Ezzikouri et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3554614/bin/pone.0054793.s001.docx
Authors & Co-Authors
Ezzikouri, Sayeh
Morocco, Casablanca
Institut Pasteur du Maroc
Alaoui, Rhimou
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Rebbani, Khadija
Morocco, Casablanca
Institut Pasteur du Maroc
Brahim, Ikram
Morocco, Casablanca
Institut Pasteur du Maroc
Fakhir, Fatima Zohra
Morocco, Casablanca
Institut Pasteur du Maroc
Nadir, Salwa
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Diepolder, Helmut Michael
Germany, Munich
Ludwig-maximilians-universität München
Khakoo, Salim I.
United Kingdom, Southampton
University of Southampton
Thursz, Mark R.
United Kingdom, London
Imperial College London
Benjelloun, Soumaya
Morocco, Casablanca
Institut Pasteur du Maroc
Statistics
Citations: 38
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0054793
e-ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study