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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder
Journal of Urology, Volume 173, No. 5, Year 2005
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Description
Purpose: We developed and validated nomograms that accurately predict disease recurrence and progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort. Methods: Univariate and multivariate logistic regression models targeted histologically confirmed disease recurrence, and focused on 2,542 patients with bladder TCC from 10 participating centers. Variables consisted of pre-cystoscopy voided urine Nuclear Matrix Protein 22 (NMP22) assay, urine cytology, age and gender. Resulting nomograms were internally validated with bootstrapping. Nomogram performance was explored graphically with Loess smoothing plots. Results: Overall 957 patients had recurrent TCC. Tumor grade and stage was available for 898 patients, including 24% grade I, 43% grade II, and 33% grade III; 45% stage Ta, 32% T1 and/or CIS, and 23% T2 or greater. Bootstrap corrected predictive accuracy for any TCC recurrence was 0.842; grade III Ta/T1 or CIS was 0.869; and T2 or higher stage TCC of any grade was 0.858, Virtually perfect performance characteristics were observed for the nomograms predicting any TCC recurrence or grade III Ta/T1 or CIS. The nomogram predicting T2 or higher stage TCC overestimated the observed probability for predicted values greater than 45%. Conclusions: We developed and internally validated nomograms that incorporate urinary NMP22, cytology, age and gender to predict with high accuracy the probability of disease recurrence and progression in patients with Ta, T1, and/or CIS bladder TCC. These nomograms could provide a means for individualizing followup in patients with Ta, T1, CIS bladder TCC. Copyright © 2005 by American Urological Association.
Authors & Co-Authors
Shariat, Shahrokh F.
United States, Dallas
Ut Southwestern Medical Center
Zippe, Craig
United States, Cleveland
Cleveland Clinic Foundation
Lübecke, Gerson
Germany, Giessen
Justus-liebig-universität Gießen
Boman, Hans
Unknown Affiliation
Sanchez-Carbayo, Marta
Spain, Salamanca
Hospital Clínico Universitario de Salamanca
United States, New York
Memorial Sloan-kettering Cancer Center
Casella, Roberto
Switzerland, Basel
Universitat Basel
Mian, Christine
Austria, Vienna
Universität Wien
Friedrich, Martin G.
Germany, Hamburg
Universität Hamburg
Eissa, S.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Akaza, Hideyuki
Japan, Tsukuba
University of Tsukuba
Sawczuk, Ihor
United States, New York
Vagelos College of Physicians and Surgeons
Serretta, Vincenzo
Italy, Palermo
Università Degli Studi Di Palermo
Huland, Hartwig
Germany, Hamburg
Universität Hamburg
Hedelin, Hans
Germany, Hamburg
Universität Hamburg
Rupesh, Raina
United States, Cleveland
Cleveland Clinic Foundation
Miyanaga, Naoto
Japan, Tsukuba
University of Tsukuba
Sagalowsky, Arthur I.
United States, Dallas
Ut Southwestern Medical Center
Wians, Frank
United States, Dallas
Ut Southwestern Medical Center
Roehrborn, C.
United States, Dallas
Ut Southwestern Medical Center
Lotan, Yair R.
United States, Dallas
Ut Southwestern Medical Center
Perrotte, Paul
Canada, Montreal
University of Montreal
Benayoun, Serge
Canada, Montreal
University of Montreal
Marberger, Michael Johann
Austria, Vienna
Universität Wien
I. Karakiewicz, Pierre I.
Canada, Montreal
University of Montreal
Statistics
Citations: 161
Authors: 24
Affiliations: 13
Identifiers
Doi:
10.1097/01.ju.0000154696.48217.75
ISSN:
00225347
Research Areas
Cancer
Study Design
Cohort Study