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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Adiponectin confers protection from acute colitis and restricts a B cell immune response
Journal of Biological Chemistry, Volume 292, No. 16, Year 2017
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Description
Adiponectin demonstrates beneficial effects in various metabolic diseases, including diabetes, and in bowel cancer. Recent data also suggest a protective role in colitis. However, the precise molecular mechanisms by which adiponectin and its receptors modulate colitis and the nature of the adaptive immune response in murine models are yet to be elucidated. Adiponectin knock-out mice were orally administered dextran sulfate sodium for 7 days and were compared with wild-type mice. The severity of disease was analyzed histopathologically and through cytokine profiling. HCT116 colonic epithelial cells were employed to analyze the in vitro effects of adiponectin and AdipoR1 interactions in colonic injury following dextran sulfate sodium treatment. Adiponectin knock-out mice receiving dextran sulfate sodium exhibited severe colitis, had greater inflammatory cell infiltration, and an increased presence of activated B cells compared with controls. This was accompanied by an exaggerated proinflammatory cytokine profile and increased STAT3 signaling. Adiponectin knock-out mouse colons had markedly reduced proliferation and increased epithelial apoptosis and cellular stress. In vitro, adiponectin reduced apoptotic, antiproliferative, and stress signals and restored STAT3 signaling. Following the abrogation of AdipoR1 in vitro, these protective effects of adiponectin were abolished. In summary, adiponectin maintains intestinal homeostasis and protects against murine colitis through interactions with its receptor AdipoR1 and by modulating adaptive immunity. © 2017 American Scientific Publishers All rights reserved.
Authors & Co-Authors
Wankell, Miriam
Australia, Melbourne
University of Melbourne
Ramezani-Moghadam, Mehdi
Australia, Parramatta
The Westmead Institute for Medical Research
Lopata, Andreas Ludwig
Australia, Melbourne
University of Melbourne
Ahlenstiel, Golo
Australia, Parramatta
The Westmead Institute for Medical Research
Qiao, Liang
Australia, Parramatta
The Westmead Institute for Medical Research
George, Jacob A.
Australia, Parramatta
The Westmead Institute for Medical Research
Hebbard, Lionel W.
Australia, Parramatta
The Westmead Institute for Medical Research
Australia, Melbourne
University of Melbourne
Australia, Townsville
James Cook University
Statistics
Citations: 32
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1074/jbc.M115.712646
ISSN:
00219258
Research Areas
Cancer
Noncommunicable Diseases
Violence And Injury