Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Mortality by baseline CD4 cell count among HIV patients initiating antiretroviral therapy: Evidence from a large cohort in Uganda
AIDS, Volume 25, No. 6, Year 2011
Notification
URL copied to clipboard!
Description
OBJECTIVE: Evaluations of CD4 cell count and other prognostic factors on the survival of HIV patients in sub-Saharan Africa are extremely limited. Funders have been reticent to recommend earlier initiation of treatment. We aimed to examine the effect of baseline CD4 cell count on mortality using data from HIV patients receiving combination antiretroviral therapy (cART) in Uganda. DESIGN: Observational study of patients aged at least 14 years enrolled in 10 clinics across Uganda for which The AIDS Support Organization (TASO) has data. METHODS: CD4 cell count was stratified into categories (<50, 50-99, 100-149, 150-199, 200-249, 250-299, >300 cells/μl) and Cox proportional hazards regression was used to model the associations between CD4 cell count and mortality. RESULTS: A total of 22 315 patients were included. 1498 patients died during follow-up (6.7%) and 1433 (6.4%) of patients were lost to follow-up. Crude mortality rates (CMRs) ranged from 53.8 per 1000 patient-years [95% confidence interval (CI) 48.8-58.8] among those with CD4 cell counts of less than 50, to 15.7, (95% CI 12.1-19.3) among those with at least 300 cells/μl. Relative to a baseline CD4 cell count of less than 50 cells/μl, the risk of mortality was 0.75 (95% CI 0.65-0.88), 0.60 (95% CI 0.51-0.70), 0.43 (0.37-0.50), and 0.41 (0.33-0.51) for those with baseline CD4 cell counts of 50-99, 100-149, 150-249, and ≥250 cells/μl, respectively. CONCLUSION: Earlier initiation of cART is associated with increased survival benefits over deferred treatment. © 2011 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Mills, Edward J.
Canada, Ottawa
University of Ottawa
Uganda, Kampala
Aids Support Organization Uganda
Bakanda, Celestin
Uganda, Kampala
Aids Support Organization Uganda
Birungi, Josephine
Uganda, Kampala
Aids Support Organization Uganda
Mwesigwa, Robert
Uganda, Kampala
Aids Support Organization Uganda
Chan, Keith J.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Ford, Nathan P.
Switzerland, Geneve
Médicins Sans Frontières Msf
Hogg, Robert S.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Cooper, Curtis L.
Canada, Ottawa
L'hôpital D'ottawa
Statistics
Citations: 91
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1097/QAD.0b013e32834564e9
e-ISSN:
14735571
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Locations
Uganda