Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Inhibitory Effects of Egyptian Folk Medicines on Human Immunodeficiency Virus (HIV) Reverse Transcriptase
Chemical and Pharmaceutical Bulletin, Volume 43, No. 4, Year 1995
Notification
URL copied to clipboard!
Description
Extracts of 41 medicinal plants used in Egyptian folk medicine were screened for their inhibitory effects on human immunodeficiency virus-1 reverse transcriptase. The extracts of fruits of Phyllanthus emblica, Quercus pedunculata, Rumex cyprius, Terminalia bellerica, Terminalia chebula and Terminalia horrida showed significant inhibitory activity with IC50≤50 μg/ml. Through a bioassay guided-fractionation of the methanol extract of the fruit of P. emblica, putranjivain A (1) was isolated as a potent inhibitory substance with IC50 = 3.9μM, together with 1,6-di-O-galloyl-β-D-glucose (2), 1-O-galloyl-β-D-glucose (3), kaempferol-3-O-β-D-glucoside (4), quercetin-3-O-β-D-glucoside (5) and digallic acid (6). The inhibitory mode of action by 1, 2 and 6 was non-competitive with respect to the substrate but competitive with respect to a template-primer. Furthermore, the stereochemistry of 1 was established in this paper by nuclear magnetic resonance spectroscopy. © 1995, The Pharmaceutical Society of Japan. All rights reserved.
Authors & Co-Authors
El-Mekkawy, Sahar A.
Japan, Toyama
University of Toyama
Meselhy, M. R.
Japan, Toyama
University of Toyama
Kadota, Shigetoshi
Japan, Toyama
University of Toyama
Hattori, Massao
Japan, Toyama
University of Toyama
Namba, Tsuneo
Japan, Toyama
University of Toyama
Statistics
Citations: 165
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1248/cpb.43.641
ISSN:
00092363
Research Areas
Cancer
Health System And Policy
Infectious Diseases