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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding
Neuroendocrinology, Volume 95, No. 4, Year 2012
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Description
Objective: Gonadotropin-inhibitory hormone (GnIH)-3 is a neuropeptide that plays a major role in the regulation of reproduction and feeding in mammals. Materials and Methods: We measured endocrine and behavioural parameters of reproduction in sheep, and sexual behaviour in sheep, mice and cynomolgus monkeys. In addition, GnIH gene expression (in situ hybridization) was examined in ewes, and effects of GnIH-3 on food intake and energy expenditure were measured in various species. GnIH-3 was infused (i.v.) into ewes after an i.m. injection of estradiol benzoate to determine whether the peptide blocks the surge in luteinizing hormone (LH) secretion. Results: GnIH gene expression was reduced in the preovulatory period in ewes. Infusion (i.v.) of GnIH-3 blocked the estrogen-induced LH surge (in ewes). Intracerebroventricular infusion had no effect on female or male sexual behaviour in each of the three species, but increased food intake. There were no effects on energy expenditure in sheep or rats. GnIH increased fos protein (immunohistochemistry) was seen in orexigenic neurons (in sheep and rats), but also in anorexigenic neurons (in sheep). Conclusions: GnIH-3 reduces reproductive hormone levels and increases food intake in mammals without reducing energy expenditure. There is minimal effect on reproductive behaviour. The dual effect on reproduction and feeding suggests that GnIH-3 provides a molecular switch between these two functions. Blockade of the positive feedback effect of estrogen with parenteral infusion indicates that this peptide may have utility as a blocker of reproductive function in mammals. Copyright © 2012 S. Karger AG.
Authors & Co-Authors
Clarke, Iain J.
Australia, Clayton
Monash University
Smith, Jeremy T.
Australia, Clayton
Monash University
Henry, Belinda A.
Australia, Clayton
Monash University
Oldfield, Brian J.
Australia, Clayton
Monash University
Stefanidis, Aneta
Australia, Clayton
Monash University
Millar, Robert P.
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
South Africa, Cape Town
University of Cape Town
Sari, Ika Puspita
Australia, Clayton
Monash University
Chng, Keefe
Singapore, Singapore City
National University of Singapore
Fabre-Nys, Claude
France, Nouzilly
Physiologie de la Reproduction et Des Comportements Prc
Caraty, Alain
France, Nouzilly
Physiologie de la Reproduction et Des Comportements Prc
Ang, Beng Ti
Singapore, Singapore City
National University Health System
Chan, Louiza
Singapore, Singapore City
National University Health System
Fraley, Gregory S.
United States, Holland
Hope College
Statistics
Citations: 153
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1159/000332822
ISSN:
00283835
e-ISSN:
14230194
Research Areas
Food Security
Genetics And Genomics
Sexual And Reproductive Health
Participants Gender
Male
Female