Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Correlation of power Doppler with microvessel density in assessing rostate needle biopsy
Clinical Radiology, Volume 59, No. 10, Year 2004
Notification
URL copied to clipboard!
Description
Aim: To correlate hypervascular power Doppler ultrasonography with the histological evaluation of microvasculature in the prostate using trans-rectal ultrasound (TRUS)-guided needle biopsy. Materials and Methods: Ninety-six patients with a lower urinary tract symptoms (LUTS) and prostate specific antigen (PSA) value more than 4 ng/ml were evaluated using power Doppler ultrasonography before biopsy. The vascularity of the peripheral zone was graded on a scale of PZ0 to PZ2. Core needle biopsies were immunostained with CD31(DAKO) and counting was performed manually on separate high power fields (HPF;×400) in areas containing the highest number of vessels. Results: There was a significant correlation between the grading system used for power Doppler and the microvessel density (MVD; PZ0 28.61±8.97,PZ1 36.00±12.11&PZ2 64.008±15.86; p<0.001). There was also a significant difference in MVD between benign, malignant and tissue cores with atypia and prostatic intra-epithelial neoplasia (PIN; p<0.001 and p<0.018, respectively). There was a significant correlation between malignant tissue having a higher Gleason score and increased MVD (p<0.001). Furthermore, cancer biopsies having a high flow PZ2 are nearly twice as likely (63.2%) to have a Gleason score of 7 or more when compared those having a Gleason score of less than 7 (36.8%). Conclusion: The grading system of assessing the power Doppler flow signals appears to be of value as an indicator of MVD. It also correlates with a higher Gleason score and this may reflect the clinical outcome in prostate cancer. It deserves further study and evaluation as a prognostic indicator. © 2004 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Wilson, N. M.
Egypt, Cairo
Ahmed Maher's Teaching Hospital
Masoud, A. M.
Egypt, Cairo
Faculty of Medicine
Barsoum, H. B.
Egypt, Cairo
Ahmed Maher's Teaching Hospital
Refaat, M. M.
Egypt, Zagazig
Zagazig University
Moustafa, M. I.
Egypt, Giza
Cairo University
Kamal, T. A.
Egypt, Zagazig
Zagazig University
Statistics
Citations: 34
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.crad.2004.03.021
Research Areas
Cancer