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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Analysis of 2,386 consecutive cycles of in vitro fertilization or intracytoplasmic sperm injection using autologous oocytes in women aged 40 years and above
Fertility and Sterility, Volume 94, No. 5, Year 2010
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Description
Objective: To estimate the live-birth and miscarriage rates in 1-year age increments for women aged ≥40 years undergoing in vitro fertilization or intracytoplasmic sperm injection (ICSI-IVF) with autologous oocytes. Design: Retrospective database and chart analysis. Setting: Egyptian IVF and embryo transfer center. Patient(s): One thousand six hundred forty-five women aged ≥40 years undergoing 2004 fresh nondonor IVF-ICSI cycles. Intervention(s): ICSI-IVF using ejaculate or surgically retrieved sperm. Main Outcome Measure(s): Pregnancy and live-birth rates per initiated cycle based on 1-year age increments. Result(s): The overall live-birth rate per initiated cycle was 6.7% (range: 10% to 0.5%). The pregnancy loss rate was 44.8% (range: 39.0% to 75.0%). The cutoff age was 43 years, when the pregnancy rate became statistically significantly lower. The live-birth rate per initiated cycle was statistically significantly higher for women <43 years old, 132 out of 1766 (7.4%) compared with women ≥43 years old, 7 out of 620 (1.1%). The miscarriage rate was 127 out of 295 (43.1%) compared with 15 out of 23 (65.2%) for the two age groups, respectively. Conclusion(s): The success rate of ICSI-IVF as measured by live-birth rate per initiated cycle was statistically significantly higher for women aged <43 years as compared with women aged ≥43 years. Once women have attained age 43 years, alternative methods such as oocyte donation cycles or previously cryopreserved embryos are likely to be more effective. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.
Authors & Co-Authors
Serour, Gamal I.
Egypt, Cairo
Al-azhar University
Egypt, Cairo
The Egyptian Ivf Center
Mansour, Ragaa T.
Egypt, Cairo
The Egyptian Ivf Center
Serour, Ahmad G.I.
Egypt, Cairo
Al-azhar University
Egypt, Cairo
The Egyptian Ivf Center
Aboulghar, Mona Mohamed
Egypt, Cairo
The Egyptian Ivf Center
Amin, Yahia M.
Egypt, Cairo
The Egyptian Ivf Center
Kamal, Omnia
Egypt, Cairo
The Egyptian Ivf Center
Al-Inany, Hesham Gaber
Egypt, Cairo
The Egyptian Ivf Center
Aboulghar, Mohamed A.
Egypt, Cairo
The Egyptian Ivf Center
Statistics
Citations: 45
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.fertnstert.2009.09.044
ISSN:
00150282
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Female