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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
TGF-β interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4
+
T cells
European Journal of Immunology, Volume 40, No. 8, Year 2010
Notification
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Description
TGF-β and IL-4 were recently shown to selectively upregulate IL-9 production by naïve CD4+ T cells. We report here that TGF-β\ interactions with IL-1α, IL-1β, IL-18, and IL-33 have equivalent IL-9-stimulating activities that function even in IL-4-deficient animals. This was observed after in vitro antigenic stimulation of immunized or unprimed mice and after polyclonal T-cell activation. Based on intracellular IL-9 staining, all IL-9-producing cells were CD4+ and 80-90% had proliferated, as indicated by reduced CFSE staining. In contrast to IL-9, IL-13 and IL-17 were strongly stimulated by IL-1 and either inhibited (IL-13) or were unaffected (IL-17) by addition of TGF-β. IL-9 and IL-17 production also differed in their dependence on IL-2 and regulation by IL-1/IL-23. As IL-9 levelswere much lower in Th2 and Th17 cultures, our results identify TGF-β/IL-1 and TGF-β/IL-4 as the main control points of IL-9 synthesis. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Authors & Co-Authors
Uyttenhove, Catherine
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Brombacher, Frank
South Africa, Cape Town
University of Cape Town
van Snick, Jacques L.
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Belgium, Brussels
De Duve Institute
Statistics
Citations: 42
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1002/eji.200940281
e-ISSN:
15214141