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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A Diagnostic Accuracy Study of Xpert®MTB/RIF in HIV-Positive Patients with High Clinical Suspicion of Pulmonary Tuberculosis in Lima, Peru
PLoS ONE, Volume 7, No. 9, Article e44626, Year 2012
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Description
Background: Diagnosis of pulmonary tuberculosis (TB) among human immunodeficiency virus (HIV) patients remains complex and demands easy to perform and accurate tests. Xpert®MTB/RIF (MTB/RIF) is a molecular TB diagnostic test which is rapid and convenient; the test requires minimal human resources and reports results within two hours. The majority of performance studies of MTB/RIF have been performed in high HIV burden settings, thus TB diagnostic studies among HIV patients in low HIV prevalence settings such as Peru are still needed. Methodology/Principal Findings: From April 2010 to May 2011, HIV-positive patients with high clinical suspicion of TB were enrolled from two tertiary hospitals in Lima, Peru. Detection of TB by MTB/RIF was compared to a composite reference standard Löwenstein-Jensen (LJ) and liquid culture. Detection of rifampicin resistance was compared to the LJ proportion method. We included 131 patients, the median CD4 cell count was 154.5 cells/mm3 and 45 (34.4%) had TB. For TB detection among HIV patients, sensitivity of MTB/RIF was 97.8% (95% CI 88.4-99.6) (44/45); specificity was 97.7% (95% CI 91.9-99.4) (84/86); the positive predictive value was 95.7% (95% CI 85.5-98.8) (44/46); and the negative predictive value, 98.8% (95% CI 93.6-99.8) (84/85). MTB/RIF detected 13/14 smear-negative TB cases, outperforming smear microscopy [97.8% (44/45) vs. 68.9% (31/45); p = 0.0002]. For rifampicin resistance detection, sensitivity of MTB/RIF was 100% (95% CI 61.0-100.0) (6/6); specificity was 91.0% (95% CI 76.4-96.9) (30/33); the positive predictive value was 66.7% (95% CI 35.4-87.9) (6/9); and the negative predictive value was 100% (95% CI 88.7 -100.0) (30/30). Conclusions/Significance: In HIV patients in our population with a high clinical suspicion of TB, MTB/RIF performed well for TB diagnosis and outperformed smear microscopy. © 2012 Carriquiry et al.
Authors & Co-Authors
Carriquiry, Gabriela
Peru, Lima
Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
Otero, Larissa
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
González-Lagos, Elsa
Peru, Lima
Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
Zamudio, Carlos Caicedo
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
Sánchez, Eduardo
Peru, Lima
Hospital Nacional Hipólito Unanue
Nabeta, Pamela
Switzerland, Geneva
Foundation for Innovative new Diagnostics, Switzerland
Campos, Miguel
Peru, Lima
Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
Echevarría, Juan
Peru, Lima
Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
Kenya, Lima
Hospital Cayetano Heredia.
Seas, Carlos
Peru, Lima
Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
Kenya, Lima
Hospital Cayetano Heredia.
Gotuzzo, Eduardo H.
Peru, Lima
Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado
Peru, Lima
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander Von Humboldt
Kenya, Lima
Hospital Cayetano Heredia.
Statistics
Citations: 50
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0044626
e-ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study