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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Anti-HIV Michellamines from Ancistrocladus korupensis
Journal of Medicinal Chemistry, Volume 37, No. 12, Year 1994
Notification
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Description
Here we report details of the isolation and determination of the absolute configurations and comparative anti-HIV activities of novel, atropisomeric naphthylisoquinoline alkaloid dimers, michellamines A, B, and C, from a newly described species of Ancistrocladus from the Korup rainforest of Cameroon. We further provide a more extensive analysis of the range of anti-HIV activity of michellamine B, the most potent and abundant member of the series. Michellamine B inhibited HIV-induced cell killing and viral replication in a variety of human cell lines, as well as in cultures of human peripheral blood leukocytes and monocytes. Michellamine B was active against a panel of biologically diverse laboratory and clinical strains of HIV-1, including the AZTresistant strain G910-6 and the pyridinone-resistant strain A17; the compound also inhibited several strains of HIV-2. © 1994, American Chemical Society. All rights reserved.
Authors & Co-Authors
Boyd, Michael R.
United States, Frederick
National Cancer Institute at Frederick
Hallock, Yali F.
United States, Frederick
National Cancer Institute at Frederick
Cardellina, John H.
United States, Frederick
National Cancer Institute at Frederick
Manfredi, Kirk P.
United States, Frederick
National Cancer Institute at Frederick
Blunt, John W.
United States, Frederick
National Cancer Institute at Frederick
McMahon, James B.
United States, Frederick
National Cancer Institute at Frederick
Buckheit, Robert W.
United States, Frederick
National Cancer Institute at Frederick
Bringmann, Gerhard
United States, Birmingham
Southern Research
Schäffer, Manuela
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Cragg, Gordon M.L.
United States, Frederick
National Cancer Institute at Frederick
Thomas, Duncan W.
United States, Corvallis
Oregon State University
Jato, Johnson G.
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 204
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1021/jm00038a003
ISSN:
00222623
e-ISSN:
15204804
Research Areas
Infectious Diseases
Study Locations
Cameroon