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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Novel 'heavy' dyes for retinal membrane staining during macular surgery: Multicenter clinical assessment
Acta Ophthalmologica, Volume 92, No. 4, Year 2014
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Description
Purpose: To evaluate the feasibility of two novel 'heavy' dye solutions for staining the internal limiting membrane (ILM) and epiretinal membranes (ERMs), without the need for a prior fluid-air exchange, during macular surgery. Methods: In this prospective nonrandomized multicenter cohort study, the high molecular weight dyes ILM-Blue™ [0.025% brilliant blue G, 4% polyethylene glycol (PEG)] and MembraneBlue-Dual™ (0.15% trypan blue, 0.025% brilliant blue G, 4% PEG) were randomly used in vitrectomy surgeries for macular disease in 127 eyes of 127 patients. Dye enhanced membrane visualization of the ILM and ERMs, 'ease of membrane peeling', visually detectable perioperative retinal damage, postoperative best-corrected visual acuity (BCVA), dye remnants and other unexpected clinical events were documented by 21 surgeons. Results: All surgeries were uneventful, and a clear bluish staining, facilitating the identification, delineation and removal of the ILM and ERMs, was reported in all but five cases. None of the surgeries required a fluid-air exchange to assist the dye application. BCVA at 1 month after surgery improved in 83% of the eyes in the MembraneBlue-Dual™ group and in 88% in the ILM-Blue™ group. No dye remnants were detected by ophthalmoscopy, and no retinal adverse effects related to the surgery or use of the dyes were observed. Conclusion: The 'heavy' dye solutions ILM-Blue™ and MembraneBlue-Dual™ can be injected into a fluid-filled vitreous cavity and may facilitate staining and removal of the ILM and/or ERMs in macular surgery without an additional fluid-air exchange. © 2013 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
Authors & Co-Authors
Veckeneer, Marc A.H.
Netherlands, Rotterdam
Oogziekenhuis Rotterdam
Mohr, Andreas M.
Germany, Bremen
St. Joseph-stift Hospital
AlHarthi, Essam M.
Saudi Arabia, Riyadh
Alhokama Eye Specialist Center
Azad, Rajvardhan
India, New Delhi
Dr. Rajendra Prasad Centre for Ophthalmic Sciences
Bashshur, Ziad F.
Lebanon, Beirut
American University of Beirut
Bertelli, Enrico
Italy, Bolzano
Div. Oculistica
Bejjani, Riad Antoine
Lebanon, Beirut
Lebanese American University
Bouassida, Brahim
Tunisia, Tunis
Clinique Ophthalmologique et O.r.l. de Tunis
Bourla, Dan Haim
Israel, Petah Tiqwa
Rabin Medical Center Israel
Crespo, Iñigo Corcõstegui
Spain, Bilbao
Instituto Clínico-quirúrgico de Oftalmología
Fahed, Charbel D.
Lebanon, Beirut
Lebanese American University
Fayyad, Faisal Tawfeeq
Jordan, Amman
Jordan Hospital
Mura, Marco
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Hilversum
Oogziekenhuis Zonnestraal - Hilversum
Nawrocki, Jerzy
Poland, Lodz
Klinika Okulistyczna
Rivett, Kelvin
South Africa
Medivision
Scharioth, Gábor B.
Germany, Recklinghausen
Aurelios Augenzentrum
Shkvorchenko, Dmitriy O.
Russian Federation, Moscow
S.n. Fyodorov Eye Microsurgery State Institution
Szurman, Peter
Germany, Sulzbach
Knappschaftskrankenhaus Sulzbach
van Wijck, Hein
South Africa, Johannesburg
Keravision
Wong, Ian Yat Hin
Hong Kong, Hong Kong
The University of Hong Kong
Wong, David Sai Hung
Hong Kong, Hong Kong
The University of Hong Kong
Frank, Johannes
Netherlands, Delft
Delft University of Technology
Oellerich, Silke
Netherlands, Rotterdam
Netherlands Institute for Innovative Ocular Surgery
Bruinsma, Marieke
Netherlands, Rotterdam
Netherlands Institute for Innovative Ocular Surgery
Melles, Gerrit R.J.
Netherlands, Rotterdam
Netherlands Institute for Innovative Ocular Surgery
Statistics
Citations: 25
Authors: 25
Affiliations: 22
Identifiers
Doi:
10.1111/aos.12208
ISSN:
1755375X
e-ISSN:
17553768
Research Areas
Environmental
Health System And Policy
Study Design
Cohort Study
Study Approach
Quantitative