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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A population-based study of reduced sleep duration and hypertension: The strongest association may be in premenopausal women
Journal of Hypertension, Volume 28, No. 5, Year 2010
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Description
Objectives: Recent evidence indicates that reduced sleep duration may be associated with an increased risk of hypertension with possibly stronger effects among women than men. We therefore examined cross-sectional sex-specific associations of sleep duration with hypertension in a large population-based sample from the Western New York Health Study (1996-2001). Methods: Participants were 3027 white men (43.5%) and women (56.5%) without prevalent cardiovascular disease (median age 56 years). Hypertension was defined as blood pressure at least 140 or at least 90 mmHg or regular use of antihypertensive medication. Multivariate logistic regression analyses were performed to estimate odds ratios (ORs) of hypertension comparing less than 6 h of sleep per night versus the reference category (≥6) while accounting for a number of potential confounders. Results: In multivariate analyses, less than 6&h of sleep was associated with a significant increased risk of hypertension compared to sleeping at least 6h per night, only among women [OR=1.66 (1.09 to 2.53)]. No significant association was found among men [OR=0.93 (0.62 to 1.41)].In subgroup analyses by menopausal status, the effect was stronger among premenopausal women [OR=3.25 (1.37 to 7.76)] than among postmenopausal women [OR=1.49 (0.92 to 2.41)]. Conclusion: Reduced sleep duration, by increasing the risk of hypertension, may produce detrimental cardiovascular effects among women. The association is independent of socioeconomic status, traditional cardiovascular risk factors, and psychiatric comorbidities, and is stronger among premenopausal women. Prospective and mechanistic evidence is necessary to support causality. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Stranges, S.
United Kingdom, Coventry
Warwick Medical School
Dorn, Joan M.
United States, Buffalo
University at Buffalo, the State University of new York
Cappuccio, Francesco Paolo
United Kingdom, Coventry
Warwick Medical School
Hovey, Kathleen M.
Unknown Affiliation
Freudenheim, Jo L.
Unknown Affiliation
Kandala, Ngianga Bakwin
United Kingdom, Coventry
Warwick Medical School
Statistics
Citations: 159
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1097/HJH.0b013e328335d076
ISSN:
02636352
Research Areas
Mental Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female