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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypes
Journal of Virology, Volume 85, No. 17, Year 2011
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Description
As part of an ongoing study of early human immunodeficiency virus type 1 (HIV-1) infection in sub-Saharan African countries, we have identified 134 seroconverters (SCs) with distinct acute-phase (peak) and early chronic-phase (set-point) viremias. SCs with class I human leukocyte antigen (HLA) variants B*44 and B*57 had much lower peak viral loads (VLs) than SCs without these variants (adjusted linear regression beta values of -1.08 ± 0.26 log 10 [mean ± standard error] and -0.83 ± 0.27 log 10, respectively; P < 0.005 for both), after accounting for several nongenetic factors, including gender, age at estimated date of infection, duration of infection, and country of origin. These findings were confirmed by alternative models in which major viral subtypes (A1, C, and others) in the same SCs replaced country of origin as a covariate (P ≤ 0.03). Both B*44 and B*57 were also highly favorable (P ≤ 0.03) in analyses of set-point VLs. Moreover, B*44 was associated with relatively high CD4 + T-cell counts during early chronic infection (P = 0.02). Thus, at least two common HLA-B variants showed strong influences on acute-phase as well as early chronic-phase VL, regardless of the infecting viral subtype. If confirmed, the identification of B*44 as another favorable marker in primary HIV-1 infection should help dissect mechanisms of early immune protection against HIV-1 infection. © 2011, American Society for Microbiology.
Authors & Co-Authors
Tang, Jianming
United States, Birmingham
The University of Alabama at Birmingham
Cormier, Emmanuel G.
United Kingdom, London
Chelsea and Westminster Hospital
Gilmour, Jill W.
United Kingdom, London
Chelsea and Westminster Hospital
Price, Matt A.
United States, New York
International Aids Vaccine Initiative
Prentice, Heather A.
United States, Birmingham
The University of Alabama at Birmingham
Song, Wei
United States, Birmingham
The University of Alabama at Birmingham
Kamali, Anatoli
Uganda
Mrc/uvri Uganda Virus Research Unit on Aids
Karita, Etienne
Rwanda, Kigali
Projet San Francisco
Lakhi, Shabir
Zambia, Lusaka
Zambia-emory Hiv Research Project
Sanders, Eduard Joachim
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
University of Oxford
Anzala, Aggrey Omu
Kenya, Nairobi
Kenya Aids Vaccine Initiative Kavi
Amornkul, Pauli N.
United States, New York
International Aids Vaccine Initiative
Allen, Susan A.
Zambia, Lusaka
Zambia-emory Hiv Research Project
United States, Atlanta
Emory University
Hunter, Eric
United States, Atlanta
Emory University
Kaslow, Richard A.
United States, Birmingham
The University of Alabama at Birmingham
Statistics
Citations: 37
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1128/JVI.00439-11
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Infectious Diseases