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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased sperm nuclear DNA damage in normozoospermic infertile men: A prospective study
Fertility and Sterility, Volume 78, No. 2, Year 2002
Notification
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Description
Objective: To evaluate levels of sperm nuclear DNA damage in infertile men with normal and abnormal standard semen parameters. Design: Prospective study. Setting: Male infertility clinic. Patient(s): Ninety-two men seeking infertility treatment and 16 fertile volunteers. Intervention(s): Standard semen analysis was performed according to the World Health Organization guidelines. Main Outcome Measure(s): Sperm DNA damage was assessed by sperm chromatin structure assay and the results expressed as %DFI. Result(s): Of the 92 patients, 21 (23%) had normal standard sperm parameters (concentration, motility, and normal sperm forms), while 71 (77%) had an abnormality in one or more of these parameters. The %DFI [median (25th and 75th percentiles)] in infertile men with normal sperm parameters [23 (15, 32)] was significantly higher than fertile donors [15 (11, 20)] (P=.02), but not significantly different from infertile men with abnormal sperm parameters [28 (18, 41)] (P=.27). Conclusion(s): The results of this study indicate that a significant increase in SCSA-defined DNA damage can be found in sperm from infertile men with normal standard sperm parameters. Therefore, sperm DNA damage analysis may reveal a hidden abnormality of sperm DNA in infertile men classified as idiopathic based on apparently normal standard sperm parameters. © 2002 American Society for Reproductive Medicine.
Authors & Co-Authors
Saleh, Ramadan Abdou
United States, Cleveland
Cleveland Clinic Foundation
Agarwal, Ashok K.
United States, Cleveland
Cleveland Clinic Foundation
Nelson, David R.
United States, Cleveland
Cleveland Clinic Foundation
Nada, E. A.
Egypt, Sohag
Faculty of Medicine
El-Tonsy, Mohammed H.
Egypt, Zagazig
Faculty of Medicine
Álvarez, Juan G.
United States, Boston
Harvard Medical School
Thomas, Anthony Joseph
United States, Cleveland
Cleveland Clinic Foundation
Sharma, Rakesh Kumar
United States, Cleveland
Cleveland Clinic Foundation
Statistics
Citations: 8
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/S0015-0282(02)03219-3
ISSN:
00150282
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Male