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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First successful allogeneic hematopoietic stem cell transplantation for a sickle cell disease patient in a low resource country (Nigeria): A case report
Annals of Transplantation, Volume 19, No. 1, Year 2014
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Description
Background: Sickle cell disease (SCD) has a prevalence of 2-3% in Nigeria (population: over 150 million). We present our first allogeneic hematopoietic stem cell transplantation (HSCT) for a 7-year-old patient with severe sickle cell anemia and debilitating right-sided hemi-paraparesis. Case Report: Conditioning was with (Reduced Intensity Conditioning (FLU/BU).[Fludarabine 160 mg/m2 (days -6 to -2) and Busulphan 16 mg/kg (4×25 mg 6 hly days -5 to -2) and Anti-thymocyte globulin(ATG)(ATGAM) total dose 500 mg (days -6 to -4)]. Graft versus Host Disease (GVHD) prophylaxis was with Cyclosporine A (2×50 mg daily) and Mycophenolate Mofetil (2×500 mg/day).Stem cell source was bone marrow harvested on the 28 September 2011 with 9.8×108 nucleated cells/kg in a total volume of 900 mL from his 14-year-old HLA-matched sibling (6/6). Neutrophil and platelet engraftment was day +18 and +21, respectively. At day +70 full blood count was a total white blood cell count of 3100/μl, absolute Neutrophil count 1200/μl, Hemoglobin (Hb) 11.3 g/dl, Platelet 198,000/μl, Hemoglobin phenotype AA, and no acute or chronic GVHD. He is clinically stable with a Chimerism at 2 years post-HSCT of 95% and responding to physiotherapy. Conclusions: We have successfully performed a stem cell transplanted in a 7-year-old Sickle Cell Anemia case. With the assistance of Government and improved Health Insurance Policy, we could make HSCT available as a cure for many Nigerians with both malignant and non-malignant disorders. © Ann Transplant.
Authors & Co-Authors
Bazuaye, Nosa
Nigeria, Benin
University of Benin
Nwogoh, Benedict
Nigeria, Benin
University of Benin
Ikponmwen, Douglas
Nigeria, Benin
University of Benin
Irowa, Omorodion O.
Nigeria, Benin
University of Benin
Okugbo, Stanley U.
Nigeria, Benin
University of Benin
Isa, Ime
Nigeria, Benin
University of Benin
Ighodaro, Emmanuel
Nigeria, Benin
University of Benin
Aina, Yetunde Isreal
Nigeria, Benin
University of Benin
Osaguona, A. O.
Nigeria, Benin
University of Benin
Idenudia, Osagie
Nigeria, Benin
University of Benin
Iyoha, Osaretin
Nigeria, Benin
University of Benin
Ighosewe, Okiroro I.
Nigeria, Abraka
Delta State University Nigeria
Osaghae, Dominic
Nigeria, Benin
Sickle Cell Centre
Bucher, Christoph
Switzerland, Basel
Universitat Basel
Statistics
Citations: 23
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.12659/AOT.890248
ISSN:
14259524
Research Areas
Cancer
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Nigeria