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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serum trace elements in obese Egyptian children: A case-control study
Italian Journal of Pediatrics, Volume 40, No. 1, Article 20, Year 2014
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Description
Background: To date, only a few studies on child obesity concerned Trace Elements (TE). TE is involved in the pathogenesis of obesity and obesity related diseases. We tried to assess trace elements status [zinc (Zn), copper (Cu), selenium (Se), iron (Fe), and chromium (Cr)] in obese Egyptian children and their relationships with serum leptin and metabolic risk factors of obesity. Methods. This was a case-control study performed with 80 obese children (BMI ≥ 95thcentile for age and gender) and 80 healthy non-obese children with comparable age and gender as the control group. For all subjects, serum Zn, Cu, Se, Fe, ferritin and Cr as well as biochemical parameters including lipid profile, serum glucose and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed. Levels of serum leptin were measured by (enzyme-linked immunosorbent assay [ELISA] method), and serum insulin was measured by an electrochemiluminesce immunoassay. Results: Compared to the control group, serum Zn, Se, and Fe levels were significantly lower (all P < 0.01) and serum Cu level was significantly higher (P < 0.01) in the obese children. Meanwhile, no significant differences were observed in serum ferritin or Cr levels (P > 0.05). A significant negative correlation was found between serum leptin and zinc levels in the obese children (r = -0.746; P < 0.01). Further, serum Zn showed significant negative correlations with total cholesterol TC levels (P < 0.05) and were positively correlated with high density lipoprotein- cholesterol HDL-C levels (P < 0.01) in the obese children. In addition, serum Se levels showed significant positive correlations with HOMA-IR values in the obese children (P < 0.01). Conclusion: The obese children may be at a greater risk of developing imbalance (mainly deficiency) of trace elements which may be playing an important role in the pathogenesis of obesity and related metabolic risk factors. © 2014 Azab et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Azab, Seham Fathy Abdelhamid H.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Saleh, Safaa Hamdy Ahmad
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Elsaeed, Wafaa Fathy Mohamed
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Elshafie, Mona A.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Sherief, Laila Metwaly
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Esh, Asmaa Mohamed Husny
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Statistics
Citations: 100
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1186/1824-7288-40-20
ISSN:
17208424
e-ISSN:
18247288
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Randomised Control Trial
Case-Control Study