Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical significance of TT virus infection in maintenance hemodialysis patients of an endemic area for hepatitis C infection
Hepatology Research, Volume 22, No. 1, Year 2002
Notification
URL copied to clipboard!
Description
Clinical significance of TTV infection was analyzed in Egyptian hemodialysis (HD) patients. Forty-seven Egyptian patients on maintenance HD and 50 age-matched volunteer blood donors were investigated. TT virus (TTV) DNA detection and genotyping were performed using a semi-nested polymerase chain reaction with specific primers. The prevalence of TTV DNA in patients on HD (66%) was significantly (P < 0.001) higher than in blood donors (24%) with genotype 1b predominance (89%) in both. Clinical background including mean age, sex, history of blood transfusion, and positive markers for either hepatitis B virus (HBV) or hepatitis C virus (HCV) did not differ between TTV DNA positive and negative HD patients. However, the mean duration of HD was significantly (P = 0.032) shorter in the TTV positive patients (28 ± 19 months) than in the negative ones (45 ± 34 months). Mean alanine aminotransferase level in patients with HCV infection alone (41 ± 24 IU/l) did not differ from that in patients with both co-infection (33 ± 28 IU/l), but was significantly higher than that in patients with TTV infection alone (26 ± 10 IU/l). Occurrence of chronic hepatic changes in patients with TTV infection alone (7%) was significantly less common than those with HCV infection alone (100%, P < 0.001) or those with both co-infection (100%, P < 0.001). Serum level of HCV core protein was similar between patients with HCV infection alone and those with co-infection with TTV. In conclusion, the prevalence of TTV infection is high in Egyptian patients on regular HD, especially with shorter duration on HD. No clinical significance of TTV virus could be elicited in HD Egyptian patients; neither it showed any clinical impact as a co-infection with HCV. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Authors & Co-Authors
Gad, Amal A.
Japan, Matsumoto
Shinshu University Faculty of Medicine
Egypt, Ismailia
Faculty of Medicine
Tanaka, Eiji
Japan, Matsumoto
Shinshu University Faculty of Medicine
Orii, Kohji
Japan, Matsumoto
Shinshu University Faculty of Medicine
Rokuhara, Akinori
Japan, Matsumoto
Shinshu University Faculty of Medicine
Nooman, Zohair M.
Egypt, Ismailia
Faculty of Medicine
El-Hamid Serwah, Abd
Egypt, Ismailia
Faculty of Medicine
El-Sherif, Assem K.
Egypt, Ismailia
Faculty of Medicine
El-Essawy, Mohamed
Egypt, Ismailia
Faculty of Medicine
Yoshizawa, Kaname
Japan, Matsumoto
Shinshu University Faculty of Medicine
Kiyosawa, Kendo
Japan, Matsumoto
Shinshu University Faculty of Medicine
Japan, Matsumoto
Graduate School of Medicine
Statistics
Citations: 10
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/S1386-6346(01)00112-7
ISSN:
13866346
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study