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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Whole blood aggregometry and platelet adenine nucleotides during cardiac surgery
Scandinavian Cardiovascular Journal, Volume 22, No. 2, Year 1988
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Description
The influence of extracorporeal circulation (ECC) on human platelet adenine nucleotides has been studied in 28 coronary bypass patients before, during and after operation. An oscillating pattern of transient increases and decreases in total platelet ATP was observed following the sternotomy until the end of the operation. A highly significant increase in platelet ATP (20%plusmn;14 of the pre-anaesthesia values) occurred during the first 24 h after surgery. Total platelet ADP however, did not show this oscillation nor was there any significant release of ADP from the platelets during ECC. Following collagen activation, increased amounts of 'releaseable ATP' were found after protaminization (124%plusmn;38 of pre-anaesthesia values) (p<0.05), although whole blood aggregability was slightly reduced (89%plusmn;18 of pre-anaesthesia values). This study indicates that 1) the metabolic ATP pool of circulating platelets underwent rapid changes during open heart surgery; 2) the majority of platelets did not release inert ADP during ECC; 3) there may be a compensatory enhancement of platelet function by other blood cells, which could explain the discrepancy between our aggregatory results in whole blood and those reported in platelet rich plasma (PRP) aggregometry. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Authors & Co-Authors
Zilla, Peter P.
Austria, Vienna
Universität Wien
Fasol, Roland
Austria, Vienna
Universität Wien
Deutsch, Manfred
Austria, Vienna
Universität Wien
Laufer, Günther M.D.
Austria, Vienna
Universität Wien
Wollenek, Gregor M.D.
Austria, Vienna
Universität Wien
Müller, Matthias M.
Austria, Vienna
Universität Wien
Knoebl, Paul N.
Austria, Vienna
Universität Wien
Vukovich, Thomas Chr
Austria, Vienna
Universität Wien
Hammerle, Alfons F.
Austria, Vienna
Universität Wien
Von-Oppell, Ulrich Otto
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 10
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.3109/14017438809105951
ISSN:
14017431
Research Areas
Health System And Policy
Noncommunicable Diseases