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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical presentation of Nipah virus infection in Bangladesh
Clinical Infectious Diseases, Volume 46, No. 7, Year 2008
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Description
Background. In Bangladesh, 4 outbreaks of Nipah virus infection were identified during the period 2001-2004. Methods. We characterized the clinical features of Nipah virus-infected individuals affected by these outbreaks. We classified patients as having confirmed cases of Nipah virus infection if they had antibodies reactive with Nipah virus antigen. Patients were considered to have probable cases of Nipah virus infection if they had symptoms consistent with Nipah virus infection during the same time and in the same community as patients with confirmed cases. Results. We identified 92 patients with Nipah virus infection, 67 (73%) of whom died. Although all age groups were affected, 2 outbreaks principally affected young persons (median age, 12 years); 62% of the affected persons were male. Fever, altered mental status, headache, cough, respiratory difficulty, vomiting, and convulsions were the most common signs and symptoms; clinical and radiographic features of acute respiratory distress syndrome of Nipah illness were identified during the fourth outbreak. Among those who died, death occurred a median of 6 days (range, 2-36 days) after the onset of illness. Patients who died were more likely than survivors to have a temperature >37.8°C, altered mental status, difficulty breathing, and abnormal plantar reflexes. Among patients with Nipah virus infection who had well-defined exposure to another patient infected with Nipah virus, the median incubation period was 9 days (range, 6-11 days). Conclusions. Nipah virus infection produced rapidly progressive severe illness affecting the central nervous and respiratory systems. Clinical characteristics of Nipah virus infection in Bangladesh, including a severe respiratory component, appear distinct from clinical characteristics reported during earlier outbreaks in other countries. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Hossain, Md Jahangir
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Gurley, Emily Suzanne
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Montgomery, Joel M.
United States, Atlanta
Centers for Disease Control and Prevention
Bell, Michael R.
United States, Atlanta
Centers for Disease Control and Prevention
Carroll, Darin S.
United States, Atlanta
Centers for Disease Control and Prevention
Formenty, Pierre Bernard Henri
Switzerland, Geneva
Organisation Mondiale de la Santé
Croisier, Alice
Switzerland, Geneva
Organisation Mondiale de la Santé
Bertherat, Eric Gerard Georges
Switzerland, Geneva
Organisation Mondiale de la Santé
Faiz, Mohammad Abul
Bangladesh, Dhaka
Dhaka Medical College and Hospital
Azad, Abul Kalam
Bangladesh, Dhaka
Ministry of Health and Family Welfare
Islam, Rafiqul M.
Bangladesh, Dhaka
Ministry of Health and Family Welfare
Ksiazek, Thomas G.
United States, Atlanta
Centers for Disease Control and Prevention
Rota, Paul A.
United States, Atlanta
Centers for Disease Control and Prevention
Comer, James Andy
United States, Atlanta
Centers for Disease Control and Prevention
Rollin, Pierre Etienne
United States, Atlanta
Centers for Disease Control and Prevention
Luby, Stephen P.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Breiman, Robert F.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Statistics
Citations: 197
Authors: 17
Affiliations: 5
Identifiers
Doi:
10.1086/529147
ISSN:
10584838
Research Areas
Health System And Policy
Participants Gender
Male