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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography
Ophthalmology, Volume 120, No. 5, Year 2013
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Description
Purpose: To assess the use of ultra-high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions. Design: Prospective, noncomparative, interventional case series. Participants: Fifty-four eyes of 53 consecutive patients with biopsy-proven ocular surface lesions: 8 primary acquired melanosis lesions, 5 amelanotic melanoma lesions, 2 nevi, 19 ocular surface squamous neoplasia lesions, 1 histiocytosis lesion, 6 conjunctival lymphoma lesions, 2 conjunctival amyloidosis lesions, and 11 pterygia lesions. Intervention: Ultra-high-resolution OCT imaging of the ocular surface lesions. Main Outcome Measures: Clinical course and photographs, UHR OCT image, and histopathologic findings. Results: Ultra-high-resolution OCT images of all examined ocular surface lesions showed close correlation with the obtained histopathologic specimens. When clinical differential diagnosis of ocular surface lesions was broad, UHR OCT images provided optical signs indicating a more specific diagnosis and management. In cases of amelanotic melanoma, conjunctival amyloidosis, and primary histiocytosis and in 1 case of ocular surface squamous neoplasia, UHR OCT was instrumental in guiding the diagnosis. In those cases, UHR OCT suggested that the presumed clinical diagnosis was incorrect and favored a diagnosis that later was confirmed by histopathologic examination. Conclusions: Correlations between UHR OCT and histopathologic findings confirm that UHR OCT is an adjunctive diagnostic method that can provide a noninvasive means to help guide diagnosis and management of ocular surface lesions. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2013 American Academy of Ophthalmology.
Authors & Co-Authors
Shousha, Mohamed Abou
United States, Miami
Bascom Palmer Eye Institute
United States, St. Louis
Saint Louis University
Egypt, Alexandria
Faculty of Medicine
Karp, Carol Lynn
United States, Miami
Bascom Palmer Eye Institute
Canto, Ana Paula
United States, Miami
Bascom Palmer Eye Institute
Hodson, Kelly L.
United States, Miami
Bascom Palmer Eye Institute
Oellers, Patrick R.
United States, Miami
Bascom Palmer Eye Institute
Kao, Andrew A.
United States, Miami
Bascom Palmer Eye Institute
Bielory, Brett Phillip
United States, Miami
Bascom Palmer Eye Institute
Matthews, Jared L.
United States, Miami
Bascom Palmer Eye Institute
Dubovy, Sander R.
United States, Miami
Bascom Palmer Eye Institute
United States, Miami
Florida Lions Ocular Pathology Laboratory
Perez, Victor L.
United States, Miami
Bascom Palmer Eye Institute
Wang, Jianhua
United States, Miami
Bascom Palmer Eye Institute
Statistics
Citations: 88
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1016/j.ophtha.2012.10.025
e-ISSN:
15494713
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cohort Study